The role of Notch in tumorigenesis: oncogene or tumour suppressor?

By Freddy Radtke, K. Raj. Nature Reviews. Cancer, 2003

886 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6e43fd89f428d7acc005190e28663ef20418d724

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In Molecular Biology

Citations in the corpus

Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “be abolished in the presence of particular oncogenic events [134].”
Notch signalling: a simple pathway becomes complex (2006, background): “jpg" NDATA ITEM> ]> Notch signalling has a simple framework that is highly conserved throughout the animal kingdo”
Oligodendrocytes: biology and pathology (2009, background): “This process involves signaling processes between the Notch1 receptor, its ligand Jagged 1 located on the axonal surface [55], and c-secretase [150, 202].”
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. (2005, neutral): “Hi 44 49% (34-64) 53 mo (30-83) NOTCH3 Lo 150 61% (53-69) 82 mo (71-122) 0.”
Radial glia cells are candidate stem cells of ependymoma. (2005, background): “Interestingly, aberrant NOTCH signaling appears to specifically transform only cells in which the G0/G1 checkpoint is disrupted (Radtke and Raj, 2003).”
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. (2006, background): “and proliferation of multiple types of cancer (52, 53).”
Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “Among the Notch family, Dll-4 and Jag-1 are the most representative ligands in tumor angiogenesis.(281,282) Highly expressed in the vasculature, Dll-4 is secreted by tip cells (differentiated from ECs) to induce excessive sprouting and increase microvessel density.”
FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations (2020, background): “In oncology studies, some genes have been identified that promote one type of cancer but suppress another type (13).”
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells (2004, background): “Conclusions Our findings regarding the role of Notch in promoting selfrenewal of mammary stem cells, in addition to previous observations that it can function as a proto-oncogene [15,16,28,33-38], suggest that abnormal Notch signaling may be involved in carcinogenesis, through deregulation of normal”
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis (2018, background): “NICD acts as a transcriptional factor and regulates downstream target genes.(180) It was reported that high-level expression of Jag1 (Jag1) and/or Notch1 (Notch1) in tumors correlated with poor outcome and is an independent prognostic indicator in primary human breast cancers.”