Lost in transcription: p21 repression, mechanisms, and consequences.

By A. Gartel, S. Radhakrishnan. Cancer Research, 2005

868 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/81ab2f692bf40261556afe6f36c0b91443cc68eb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. T. Tchkonia
2. Yi Zhu
3. M. Hollstein
4. S. Khosla
5. W. Du
6. J. Kirkland
7. Weining Yang
8. Zhenguo Yang

In Oncology

1. M. Hollstein
2. S. Khosla
3. J. Kirkland

Citations in the corpus

• Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022, background): “, a quiescent, non-dividing stage) due to activation of the p53-regulated cyclin-dependent kinase inhibitor p21, which halts cell cycle progression and inhibits DNA synthesis [23,24].”
• The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs (2015, background): “Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. p21 and PAI-1, both regulated by p53, are implicated in protection of cancer and other cell types from apoptosis (Gartel & Radhakrishnan, 2005; Kortlever et al., 2006; Schneider et al., 2008; Vousden & Prives, 2009).”
• Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (2016, background): “cell cycle progression at the G1 and S phase (17).”
• p53 polymorphisms: cancer implications (2009, background): “It is induced by wild-type p53 following DNA damag”