Notch1 functions as a tumor suppressor in mouse skin

By M. Nicolas, A. Wolfer, K. Raj, J. Kummer, P. Mill, M. van Noort, C. Hui, Hans Clevers, G. Dotto, Freddy Radtke. Nature Genetics, 2003

1,037 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/42127b463d18a43880d7da2c0aa60fbbd020e903

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Citations in the corpus

Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “Furthermore, conditional ablation of Notch1 leads to a similar phenotype in mice, which is also due to activation of the Wnt pathway (Nicolas et al., 2003).”
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 (2013, background): “For example, in the skin-specific Notch1 KO or dominant negative MAML1 transgenic mice, spontaneous skin tumors were observed (30, 31, 41).”
p63 is the molecular switch for initiation of an epithelial stratification program. (2004, background): “…the cell cycle and commitment to terminal differentiation may be partially orchestrated by signaling through Notch and IKK␣, two molecules required for terminal differentiation of the epidermis (Hu et al. 1999; Takeda et al. 1999; Rangarajan et al. 2001; Nickoloff et al. 2002; Nicolas et al. 2003).”
Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition (2004, background): “While Tgfb1 and Notch1 may function as tumor suppressors in skin by main- taining epidermal homeostasis (Cui et al, 1996; Nicolas et al, 2003), both may also exert overlapping oncogenic activities in skin cancer progression that is characterized by EMT (Cui et al, 1996; Weijzen et al, 2002).”
Epidermal stem cells of the skin. (2006, background): “Related to the natural role of Notch signaling in skin, loss of Notch 1 potentiates skin tumor development upon chemically induced carcinogenesis (Nicolas et al. 2003).”
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. (2004, background): “A recent report has shown that Notch1 deletion in the epidermis leads to increased levels of free -catenin (Nicolas et al. 2003); PAE-N1IC expressing cells do not show alterations in -catenin levels or subcellular localization (data not shown), suggesting that Notch does not affect Wnt signaling in…”
Notch signaling: control of cell communication and cell fate (2004, background): “Conversely, cells that are mutant for Notch1form skin and corneal tumors in mice, indicating that Notch also suppresses tumorigenesis (Nicolas et al., 2003).”