Hippocampal volume and depression: a meta-analysis of MRI studies.

By Poul Videbech, Barbara Ravnkilde. American Journal of Psychiatry, 2004

1,641 citations recorded by the source corpus.

Subfields: Pharmacology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/2d36931eb9db03b65d01afe8b84b5f80df87c02c

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In Pharmacology

In Psychiatry and Mental health

Citations in the corpus

Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, positive): “These results agree with evidence of volume loss in these regions as shown by structural magnetic resonance imaging (MRI) (8,9).”
A meta-analysis of structural brain abnormalities in PTSD. (2006, background): “Because abnormalities in similar brain regions have been reported for other disorders such as depression (e.g., Campbell et al., 2004; Lange and Irle, 2004; Sheline et al., 1998; Videbech and Ravnkilde, 2004), a question of continued importance is whether they represent distinct etiological factors ”
Glutamate NMDA receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure (2011, positive): “Dendritic atrophy of PFC neurons in response to chronic CUS is consistent with previous reports with other paradigms such as chronic restraint stress (15–19), and provides a cellular mechanism that could explain the decreased PFC volume reported in depressed patients (20-23).”
Adult hippocampal neurogenesis in depression (2007, result): “Magnetic resonance imaging studies have consistently shown a reduction in hippocampal volume, and two meta-analyses have compellingly demonstrated a reduction in hippocampal volume in people with recurrent depression relative to age- and sex-matched control”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “…1998, 1999, 2003; Shah et al., 1998; Bremner et al., 2000; Mervaala et al., 2000; Steffens et al., 2000; Frodl et al., 2002; MacQueen et al., 2003; Saarelainen et al., 2003; Vermetten et al., 2003; Videbech and Ravnkilde, 2004; Hickie et al., 2005; Neumeister et al., 2005; Janssen et al., 2007).”
A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. (2008, background): “, 2008) as well as lower hippocampal volume that is associated with depression (Campbell et al., 2004; Videbech and Ravnkilde, 2004) – moreover, hippocampal and hypothalamic– pituitary–adrenal axis dysfunction is associated with significant depressive symptoms, such as memory deficit and cognitive i”
The chronic mild stress (CMS) model of depression: History, evaluation and usage (2016, background): “There are also morphological parallels between CMS and depression: in particular, the major structural change that is reliably reported in the depressed brain is a decrease in the volume of the hippocampus (Campbell et al., 2004; Videbech and Ravnkilde, 2004), an effect that is also associated with ”
Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior (2012, background): “Dysfunction in the activity of these regions is strongly implicated in major depressive disorder (Sheline et al., 1998; Videbech and Ravnkilde, 2004).”
Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats (2010, neutral): “The hippocampus, a brain region involved in learning and memory, is susceptible to the effects of stress and shows a reduced volume in depressive patients (Axelson et al. 1993; Bremner et al. 2000; Campbell et al. 2004; Janssen et al. 2004; Sheline et al. 1999; Videbech and Ravnkilde 2004).”