Embryogenesis: Demethylation of the zygotic paternal genome

By W. Mayer, A. Niveleau, Jörn Walter, R. Fundele, T. Haaf. Nature, 2000

1,156 citations recorded by the source corpus.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/4d8597b6ca72bc0b69e9a45228105f7d6a36fe6e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Yi Zhang
2. Wolf Reik
3. A. Bird
4. Hao Wu
5. E. Li
6. Manel Esteller
7. W. Dean
8. Dirk Schübeler

In Public Health, Environmental and Occupational Health

1. Wolf Reik
2. R. Jaenisch

In Reproductive Medicine

1. Wolf Reik

Citations in the corpus

• Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine (2011, background): “The maternal genome later on undergoes passive demethylation in the absence of maintenance methyltransferase DNMT1 during DNA replication in cleavage-stage embryos (11, 13, 16).”
• DNA Demethylation Dynamics (2011, background): “A few early studies implicated demethylation of DNAby a rapid and active mechanism, independent of cell division (Mayer et al., 2000; Oswald et al., 2000; Paroush et al., 1990; Zhang et al., 2007), but how this active removal is achieved remained a mystery.”
• Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010, background): “…DNA methylation patterns undergo genome-wide alterations that occur immediately after fertilization and during early preimplantation development (Mayer et al., 2000; Reik et al., 2001) and that enrichment of individual histone modifications (such as H3K9me, H3K4me and H3K27me3) also varies in a…”
• Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage (2002, background): “We suggest that oxidative demethylation requiring free-radical chemistry could be involved in other mechanisms of active removal of chemically stable adducts from DNA or histones, for example, the 5-methylcytosine demethylase activit”
• Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse (2003, methodology): “This has been identified both by immunofluorescence using an antibody against 5-methyl cytosine (Mayer et al., 2000; Dean et al., 2001; Santos et al., 2002) and by bisulphite analysis of single-copy sequences (Oswald et al., 2000).”
• Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, positive): “This is based on the fact that ESCs are derived from blastocystes after a global DNA demethylation event (Howlett and Reik, 1991; Mayer et al., 2000).”