Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

By S. Trewick, Timothy F. Henshaw, Robert P. Hausinger, Tomas Lindahl, B. Sedgwick. Nature, 2002

726 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/632ad3c0badd638110c86224c6ea8a4ce6489171

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Citations in the corpus

Histone demethylation by a family of JmjC domain-containing proteins (2006, background): “In addition, our study also indicates that histone demethylation catalysed by JmjC domain proteins uses the same oxidative demethylation mechanism used by the AlkB family of DNA demethylases 11,12 .”
Alkylation damage in DNA and RNA--repair mechanisms and medical significance. (2004, background): “Shortly later two groups were able to confirm the predicted enzyme activity [45,46].”
Oxygen sensing by HIF hydroxylases (2004, background): “The precise definition of the in vivo roles of ascorbate is of increasing interest, not only because of its potential involvement in the hypoxic response, but also because of its possible role in DNA repair through stimulation of the 2-oxoglutarate-dependent-oxygenase Alk”
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility (2012, neutral): “…catalyze a wide range of biological oxidations (Dango et al., 2011; Duncan et al., 2002; Falnes et al., 2002; Fu et al., 2010; Gerken et al., 2007; Sedgwick, 2004; Trewick et al., 2002; van den 2 Molecular Cell 49, 1–12, January 10, 2013 ª2013 Elsevier Inc. Born et al., 2011; Yi et al., 2010).”
13 reasons why the brain is susceptible to oxidative stress (2018, background): “required to understand oxidised RNA recognition, turnover and repair [283].”
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “and Sarah CT et al.(241) revealed a third type of direct reversal mechanism for DNA damage, reporting that AlkB protein in E.”
Active DNA demethylation: many roads lead to Rome (2010, background): “Using oxygen, iron and 2OG as cofactors, AlkB is able to carry out oxidative demethylation of 1-methyladenine and 3meC by releasing the methyl group as formaldehyd”
Active DNA Demethylation Mediated by DNA Glycosylases (2009, neutral): “The Alkb family of enzymes can remove the methyl group from 1-methyladenine and 3-methylcytosine by oxidative demethylation, employing Fe(II) and alpha-ketoglutarate as cofactors, and release the methyl moiety as formaldehyde (24, 95).”
Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes (2004, background): “…family, especially if inhibitors or poor substrates are included (e.g., lysyl hydroxylase (Puistola et al., 1980), thymine hydroxylase (Hsu et al., 1981), γ -butyrobetaine hydroxylase (Holme et al., 1984), TfdA (Saari & Hausinger, 1998), and AlkB (Trewick et al., 2002; Welford et al., 2003)).”
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (2006, methodology): “In an effort to identify histone demethylases that differ from the LSD1 family of proteins, we have developed an in vitro histone demethylase assay based on the mechanism used by the DNA repair demethylase AlkB (Falnes et al., 2002; Trewick et al., 2002).”
Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. (2008, background): “org Volume 118 Number 6 June 2008 dent upon the presence of an iron-binding domain (34, 35), which would be inactivated under conditions of oxidative stress that are present in IUGR islets (5).”
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. (2008, background): “2007) and the previously identified AlkbH enzymes (Falnes et al. 2002; Trewick et al. 2002) that catalyze the removal of methyl groups from alkylated nucleotides.”