Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

By Khursheed Iqbal, Seung-Gi Jin, G. Pfeifer, P. Szabó. Proceedings of the National Academy of Sciences of the United States of America, 2011

704 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/13639952c57504f56e81f7459e51169a8cadfe15

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Yi Zhang
2. Hao Wu
3. Chuan He
4. Peng Jin
5. Qing Dai
6. Chun-Xiao Song
7. Bing Ren
8. David M. Burns

In Molecular Biology

1. Hao Wu
2. Yi Zhang
3. Chuan He
4. Bing Ren
5. J. Wagner
6. Qing Dai
7. J. Cadet
8. Peng Jin

In Pediatrics, Perinatology and Child Health

1. Yi Zhang
2. Hao Wu

Citations in the corpus

• Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “Recent studies indicate that the loss of paternal DNA methylation coincides with a rapid increase in 5hmC (Inoue and Zhang, 2011; Iqbal et al., 2011; Wossidlo et al., 2011) and 5fC/5caC (Inoue et al., 2011), suggesting that TET-mediated 5mC oxidation is involved in the erasure of 5mC. Knockdown or…”
• DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “It was only after the description of 5hmC, the oxidation product of 5mC by GENES & DEVELOPMENT 819 TET enzymes, that a unifying explanation came to hand (Gu et al. 2011; Iqbal et al. 2011; Wossidlo et al. 2011).”
• Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “Role of Tet1 in regulating pluripotency and lineage differentiation of mouse ES cells Concomitant with the rapid reduction of Tet3 expression at the two-cell stage, the expression of Tet1 is rapidly upregulated at later preimplantation stages (Iqbal et al. 2011; Wossidlo et al. 2011).”
• Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome (2012, positive): “The TET proteins, which are responsible for conversion of 5mC to 5hmC, have been shown to function in ESC regulation, myelopoiesis and zygote development (Dawlaty et al., 2011; Gu et al., 2011; Iqbal et al., 2011; Ito et al., 2010; Ko et al., 2010; Koh et al., 2011; Wossidlo et al., 2011).”
• DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. (2013, background): “1996), were found to be generated enzymatically and play a role in epigenetics (Kriaucionis and Heintz 2009; Tahiliani et al. 2009; Iqbal et al. 2011; Münzel et al. 2011; Pfaffeneder et al. 2011).”
• DNA Demethylation Dynamics (2011, background): “More recent studies have revealed that the active loss of 5mC is actually a conversion of 5mC to 5hmC in a TET3-dependent manner (Iqbal et al., 2011; Wossidlo et al., 2011).”