Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

By T. Cupedo, N. Crellin, N. Papazian, E. Rombouts, K. Weijer, J. Grogan, W. Fibbe, J. Cornelissen, H. Spits. Nature Immunology, 2009

700 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/4865aa7498f59e725ab7b470ea792037f9430e99

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In Immunology

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Citations in the corpus

• Fish Cytokines and Immune Response (2012, background): “In mammals, interleukin-22 is secreted by Th17 cells [196], as well as by a subset of NK cells, designated as NK22 [197]; and even by some Th1 cells [198].”
• Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes (2010, positive): “…of IL-22-producing lymphocytes coexpressing RORgt and activating NKRs (i.e., NKp46+RORgt+ cells) that localized within the intestinal lamina propria was identified (Cella et al., 2009; Cupedo et al., 2009; Hughes et al., 2009; Luci et al., 2009; Sanos et al., 2009; Satoh-Takayama et al., 2008).”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “1int) [Cupedo et al., 2009; Luci et al., 2009; Sanos et al., 2009] (Figure 4).”
• CD4+ lymphoid tissue inducer cells promote innate immunity in the gut (2010, background): “…NKp46 was found to express IL-22 in response to IL-23 stimulation or after exposure to the enteric pathogen Citrobacter rodentium and was implicated in promoting host-protective immunity (Cella et al., 2009; Cupedo et al., 2009; Luci et al., 2009; Sanos et al., 2009; Satoh- Takayama et al., 2008).”
• RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells (2009, methodology): “That view is supported by data demonstrating that human CD127 + RORγt + fetal LTi cells can differentiate into CD56 + CD127 + RORγt + NK-like cell”
• The Microbiome in Infectious Disease and Inflammation (2012, positive): “Human LTi cells have been detected in fetal MLNs, although they do not express CD4 (195).”
• Innate IL-17-producing cells: the sentinels of the immune system (2010, background): “In addition, both mouse and human LTi cell populations can produce IL-22 following stimulation ex vivo with PMA and ionomycin or with TLR agonist”