Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.

By F. Magkos, G. Fraterrigo, Jun Yoshino, C. Luecking, Kyleigh Kirbach, Shannon C. Kelly, L. de las Fuentes, Songbing He, A. Okunade, B. Patterson and 1 more. Cell Metabolism, 2016

797 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/0f2f36ca5ef330739f2bf66a0df31bbe31984733

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In Cardiology and Cardiovascular Medicine

In Epidemiology

In Physiology

Citations in the corpus

Once-Weekly Semaglutide in Adults with Overweight or Obesity. (2021, background): “, prediabetes, hypertension, and obstructive sleep apnea).(1,20,21,27) In the semaglutide group, approximately 70% of participants achieved a weight loss of at least 10%, and approximately 50% achieved a weight loss of at least 15%.”
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes (2020, background): “The improved glycemic control after weight loss is due, in part, to the dysregulated expression of genes involved in cholesterol flux, lipid synthesis, ECM remodeling, and oxidative stress (Magkos et al., 2016).”
Why Does Obesity Cause Diabetes? (2022, background): “…plasma triglyceride and increased HDL-cholesterol concentrations, decreased fasting blood glucose and insulin concentrations, increased oral glucose tolerance and insulin sensitivity, and decreased risk of type 2 diabetes in people who are lean, overweight, or obese (Manolopoulos et al., 2010).”
Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications (2019, background): “Nevertheless, these approaches are difficult to maintain in the long term [8].”
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “It has been suggested that pronounced weight loss over time can lead to improvements in adipose tissue inflammation that were not observed in the same subjects following acute moderate weight loss (552).”
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. (2019, background): “Even 48 h of calorie restriction causes a marked decline in IHTG content (50), and at any given percent weight loss, the relative decrease in IHTG content is much greater than the relative decrease in whole-body or intra-abdominal adipose tissues (51).”