Circular intronic long noncoding RNAs.

By Yang Zhang, Xiao-Ou Zhang, Tian Chen, Jian-Feng Xiang, Qing-Fei Yin, Yu-Hang Xing, Shanshan Zhu, Li Yang, Ling-Ling Chen. Molecules and Cells, 2013

2,068 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/289e6365b5cbd73d57b6b3a623997e382ca89790

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In Molecular Biology

Citations in the corpus

Using circular RNA as a novel type of biomarker in the screening of gastric cancer. (2015, background): “CircRNAs may arise from exons or introns [20].”
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs (2016, positive): “Total RNA isolation, polyadenylated/nonpolyadenylated RNA separation, RNase R treatment and RNA-seq were performed as described (Yang et al. 2011; Zhang et al. 2013; Yin et al. 2015).”
The Landscape of long non-coding RNA classification (2015, positive): “Some of these transcripts likely represent circular intronic ncRNAs (ciRNAs) (produced from introns that escape debranching) that can accumulate in cells and regulate expression of their parent genes [55] (Figure 1).”
Efficient backsplicing produces translatable circular mRNAs (2015, background): “In addition, circRNA can also be generated through 3′ exonucleolytic degradation of lariat RNAs that are splicing byproducts, resulting an intronic circRNAwith 2′,5′-phosphodiester bond (Zhang et al. 2013).”
Regulation of circRNA biogenesis (2015, background): “These non-polyadenylated signals were further confirmed as circular RNAs from back-spliced exons (circRNAs)(16) or stabilized introns, having escaped debranching (circular intronic RNAs, ciRNAs).(17) Nowadays, circRNAs have been extensively identified among a variety of transcriptomes.”
The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “Based on different combinations of exons and introns in the final circRNA sequence, circRNA can be divided into three categories that include exonic circRNA [24], circular intronic [26] and”
Circular RNA-protein interactions: functions, mechanisms, and identification (2020, background): “Furthermore, ci-ankrd52 and ci-sirt-7 were found to interact with the RNA Pol II elongation complex, and suppression of these circRNAs led to decreased transcription levels of the ankyrin repeat proteins, Ankyrin Repeat Domain 52 (ANKRD52) and Sirtuin 7 (SIRT7), respectively [33].”
Linking Long Noncoding RNA Localization and Function. (2016, background): “They can be derived from the inefficient debranching of lariat introns (see Figure 1H in main text) [63] or from pre-mRNAs backsplicing of exons (see Figure 1I in main text).”
CIRI: an efficient and unbiased algorithm for de novo circular RNA identification (2015, background): “It has to be mentioned that an intronic circRNA is different from a lariat or a 'circular intronic long noncoding RNA' [22].”
Circular RNAs: diversity of form and function (2014, background): “…accumulate in the nucleus and, where examined, can be localized to their sites of transcription (Kopczynski and Muskavitch 1992; Qian et al. 1992; Zhang et al. 2013). www.rnajournal.org 1831 Circular RNA intermediates in RNA processing reactions Circular RNAs can be produced as intermediates in…”