5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

By L. Pezawas, Andreas Meyer-Lindenberg, Emily M. Drabant, Beth A. Verchinski, Karen E. Muñoz, Bhaskar S. Kolachana, Michael Egan, Venkata S. Mattay, Ahmad R. Hariri, Daniel R. Weinberger. Nature Neuroscience, 2005

1,996 citations recorded by the source corpus.

Subfields: Clinical Psychology, Experimental and Cognitive Psychology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/4cb5042c9f9010d61cc9b5745c51420f8c96c2f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Psychology

In Experimental and Cognitive Psychology

In Psychiatry and Mental health

Citations in the corpus

Amygdala-frontal connectivity during emotion regulation. (2007, background): “…correlations in activation signal between or coactivation of amygdala and frontal cortex, specifically the OFC/ventral MPFC (Kim et al., 2004; Heinz et al., 2005; Schmitz and Johnson, 2006), dorsal MPFC (Williams et al., 2006) and ACC (Das et al., 2005; Pezawas et al., 2005; Williams et al., 2006).”
The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-Analysis Revisited: Evidence of Genetic Moderation (2011, result): “In addition, our results are consistent with a wide range of experimental neuroscience studies that have found increased stress reactivity among 5-HTTLPR s allele carriers.(87-89) Evidence from animal studies also supports that functional variation in the serotonin transporter (SERT) gene affects be”
Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “This more dorsal region shows structural and functional correlations with acquisition of conditioned fear (Milad et al, 2007a), and is overactive in carriers of the serotonin transporter 'S' allele (Pezawas et al, 2005).”
Functional Connectivity of the Human Amygdala using Resting State fMRI (2008, methodology): “The current study delineated patterns of connectivity that have been shown to be altered in clinical populations using task-based methods (Heinz et al., 2005;McClure et al., 2007; Pezawas et al., 2005; Quirk and Gehlert, 2003).”
Connectivity-Based Parcellation of Human Cingulate Cortex and Its Relation to Functional Specialization (2009, positive): “Changes in activity and structure, especially in amygdala and perigenual cingulate cortex, have been reported in depression (Mayberg et al., 2005; Pezawas et al., 2005).”
The structural and functional connectivity of the amygdala: From normal emotion to pathological anxiety (2011, background): “Similar to he inhibition of previously conditioned fear responses during fear xtinction, reduced anxiety is associated with the top-down reguation of amygdala activity by the mPFC [9,65,95].”
Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo task. (2008, background): “gions has been shown to correlate with levels of trait anxiety in adults, such that individuals with tighter coupling have lower trait anxiety (18), emphasizing the importance of prefrontal – amygdala interactions in emotion regulation.”
The self-regulating brain: Cortical-subcortical feedback and the development of intelligent action (2007, background): “However, the ACC is also connected with the amygdala (AM), hypothalamus (HTh), and brain stem, such that it can directly influence structures that mediate associative memories, emotional responses, primitive behavioural routines, and the physiological states necessary to support them (Critchley et a”
Culture–gene coevolution of individualism–collectivism and the serotonin transporter gene (2009, background): “…to emotional stimuli (Hariri et al. 2002; Munafò et al. 2008), which is likely due to increased amygdala resting activation (Canli et al. 2005) and decreased functional coupling between the amygdala and subgenual cingulate gyrus (Pezawas et al. 2005), relative to individuals carrying the L allele.”
The neurobiology of aggression and violence (2015, background): “Finally, polymorphisms of the 5-HT transporter have been associated with differential amygdala-PFC connectivity.(60,61) Therefore, it is becoming increasingly clear that while both the amygdala and ventral and medial aspects of the PFC are involved in aggression, it is essential that their concerted”
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans (2005, methodology): “As described previously (Pezawas et al., 2005), this ROI was defined by a combined functional and anatomical criterion by selecting all voxels in the anatomical amygdala region [according to the Wake Forest University (WFU) PickAtlas software; http://www.”