An engram found? Evaluating the evidence from fruit flies.

By B. Gerber, Hiromu Tanimoto, Martin Heisenberg. 2004

190 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Insect Science, Sensory Systems

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, methodology): “…and odor-sugar associative memory We asked which MBONs were required for aversive and appetitive odor memory, using a wellestablished discriminative olfactory learning paradigm (Figure 6A) (Tempel et al., 1983; Tully and Quinn, 1985; Schwaerzel et al., 2003; Gerber et al., 2004; Davis, 2005).”
Specific dopaminergic neurons for the formation of labile aversive memory (2010, unknown): “, the presynaptic terminals of Kenyon cells) upon internal convergence of neuronal signals of odor and electric shock [2, 6, 7].”
Pain-relief learning in flies, rats, and man: basic research and applied perspectives (2014, background): “…because despite the rich literature on punishment–learning (e.g., for reviews regarding Drosophila, see: Dubnau and Tully 2001; Heisenberg 2003; Gerber et al. 2004; Davis 2005; Keene and Waddell 2007; Kahsai and Zars 2011; regarding Aplysia, see: Lechner and Byrne 1998; Baxter and Byrne 2006;…”
Induction of aversive learning through thermogenetic activation of Kenyon cell ensembles in Drosophila (2014, background): “Altogether, these data have led to the hypothesis that the neuronal changes which mediate the behavioral changes caused by learning, i.e., the memory engram, can be allocated to the mushroom body (Heisenberg, 2003; Gerber et al., 2004; Fiala, 2007).”
Mushroom bodies regulate habit formation in Drosophila. (2008, unknown): “The current consensus is that the memory trace formed during this kind of learning lies within the MB Kenyon cells [22–24].”
Punishment prediction by dopaminergic neurons in Drosophila. (2005, unknown): “In particular, the mushroom bodies have been shown to be necessary for aversive olfactory memory formation [6].”
Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body (2007, background): “, olfactory memory has been proposed to be stored predominantly in the mushroom body neuron”
Memory Engram Cells Have Come of Age. (2015, unknown): “Three Types of Supporting Evidence The search for memory engrams conducted to date can be divided into the following types: observational, loss-of-function, and gain-of-function experiments (Gerber et al., 2004; Martin and Morris, 2002).”
Testing odor response stereotypy in the Drosophila mushroom body. (2008, unknown): “This issue is generally important because it relates to the specification of sensory network connectivity: at what level (if at all) does the order that exists in early circuits break down, such that connections and cellular properties become specific to each individual animal? In insects, PNs form ”
Reward signal in a recurrent circuit drives appetitive long-term memory formation (2015, unknown): “Dopamine has been thought to simply relay rewarding or punitive stimuli (Gerber et al., 2004; Waddell, 2013).”
Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. (2015, background): “The mushroom bodies (MBs) are the central integrative brain region for associative memory (de Belle and Heisenberg, 1994; Gerber et al., 2004; Krashes et al., 2007).”
Bruchpilot, A Synaptic Active Zone Protein for Anesthesia-Resistant Memory (2011, background): “1A) (Connolly et al., 1996; Aso et al., 2009), because the output synapses of these neurons are thought to undergo associative plasticity (Heisenberg, 2003; Gerber et al., 2004).”