Bruchpilot, A Synaptic Active Zone Protein for Anesthesia-Resistant Memory
By Stephan Knapek, Stephan J. Sigrist, Hiromu Tanimoto. 2011
60 citations recorded by the source corpus.
In Drosophila, aversive associative memory of an odor consists of heterogeneous components with different stabilities. Here we report that Bruchpilot (Brp), a ubiquitous presynaptic active zone protein, is required for olfactory memory. Brp was shown before to facilitate efficient vesicle release, particularly at low stimulation frequencies. Transgenic knockdown in the Kenyon cells of the mushroom body, the second-order olfactory interneurons, revealed that Brp is required for olfactory memory. We further demonstrate that Brp in the Kenyon cells preferentially functions for anesthesia-resistant memory. Another presynaptic protein, Synapsin, was shown previously to be required selectively for the labile anesthesia-sensitive memory, which is less affected in brp knockdown. Thus, consolidated and labile components of aversive olfactory memory can be dissociated by the function of different presynaptic proteins.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Sensory Systems
How researchers see this paper
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In Cellular and Molecular Neuroscience
- Yoshinori Aso
- Gerald M. Rubin
- Hiromu Tanimoto
- P. Plaçais
- T. Préat
- Severine Trannoy
- Nobuhiro Yamagata
- Toshiharu Ichinose
In Molecular Biology
In Sensory Systems
- T. Préat
- Yoshinori Aso
- Severine Trannoy
- P. Plaçais
- Gerald M. Rubin
- Stephan Knapek
- Lisa Scheunemann
- Emna Bouzaiane
Citations in the corpus
- Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “Two memory processes that are thought to rely on different molecular and circuit mechanisms, anesthesia resistant memory and anesthesia sensitive memory, contribute to memory at this retention time (Dudai et al., 1976; Folkers et al., 1993; Isabel et al., 2004; Krashes and Waddell, 2008; Aso et al.,”
- Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. (2015, background): “However, one study recently reported that immediate memory contains an anesthesia-resistant component (Knapek et al., 2011).”
- Short Neuropeptide F Acts as a Functional Neuromodulator for Olfactory Memory in Kenyon Cells of Drosophila Mushroom Bodies (2013, methodology): “To quantify sNPF levels after thermo-activation of Kenyon cells, we measured sNPF immunofluorescence in single optical sections at the anterior end of the MB peduncle using the histogram tool of ImageJ, (National Institutes of Health, Bethesda, MD; http://rsb.info.nih.gov/ij) (Knapek et al., 2011).”