Genetic and epigenetic regulators of pluripotency.

By M. Surani, Katsuhiko Hayashi, P. Hájková. Cell, 2007

646 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4c8aa40bf852c9c3b67a3b1e19f856e2722546a6

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In Molecular Biology

Citations in the corpus

Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. (2012, neutral): “Because reprogramming requires a vast number of epigenetic changes, we chose a group of ESC-associated chromatinremodeling genes and modification enzymes (Myst3, Kdm1, Hdac1, Dnmt1, Prmt7, Ctcf, Myst4, Dnmt3b, Ezh2, Bmi1) (Reik, 2007; Surani et al., 2007).”
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain (2011, neutral): “In the zygote, DNA methylation of the paternal, but not maternal, pronucleus is rapidly lost at the genome-wide scale (Mayer et al., 2000; Oswald et al., 2000; Surani et al., 2007).”
Stability and flexibility of epigenetic gene regulation in mammalian development (2007, background): “Special epigenetic regulation needs to occur in PGCs developing in the early post-implantation embry”
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine (2011, background): “Despite the relatively stable and heritable features of DNA methylation in somatic cells, genomewide DNA demethylation occurs both in developing primordial germ cells and in fertilized oocytes (zygotes) (11, 12).”
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. (2008, background): “Multiple signaling molecules, together with the transcription and epigenetic factors, play an essential role in maintaining pluripotency in ESCs (Chambers and Smith, 2004; Surani et al., 2007 ).”
The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells (2012, background): “Epigenetic information in the mammalian genome is relatively stable in differentiated cells of the soma but is reprogrammed on a genome-wide scale in primordial germ cells (PGCs) and early embryos (Reik et al., 2001; Surani et al., 2007; Sasaki and Matsui, 2008; Smith et al., 2012).”
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. (2007, background): “As a result, extensive studies in recent years have focused on understanding the genetic and epigenetic regulation of the ‘‘stemness’’ property of ES cells and their differentiation ( Surani et al., 2007 ).”
Epigenetics in cancer. (2010, background): “Since epigenetic mechanisms are central to maintenance of stem cell identity [33,122], it is reasonable to speculate that their disruption may give rise to a high risk aberrant progenitor cell population which can undergo transformation on gain of subsequent genetic gatekeeper mutations.”
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. (2011, background): “The reprogramming of DNA methylation has a direct influence on genomic imprints, the regulation of pluripotency and stem cell networks, the erasure of epimutations and the transcriptional control of transposon”
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells (2007, background): “We found that their resolution in lineage-committed cells is closely related to their demonstrated developmental potential (Supplementary Table 6): (1) genes restricted to regulation or specialized functions in unrelated lineages, such as haematopoietic (Cdx4, PU.”
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation (2009, background): “during this process of fate determination (Surani et al., 2007).”
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008, background): “The sequences described above may function as templates for the robust assembly and appropriate positioning of PcG complexes and bivalent domains during pre-implantation development or the artificial reprogramming of somatic cells to iPS cells [1,28].”