5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.

By Mark Wossidlo, Toshinobu Nakamura, K. Lepikhov, C. Marques, V. Zakhartchenko, M. Boiani, Julia Arand, T. Nakano, Wolf Reik, Jörn Walter. Nature Communications, 2011

806 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f62daaa014d9bb9d3ab67eedde6b24be2349f007

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In Molecular Biology

1. Hao Wu
2. Yi Zhang
3. Chuan He
4. Aviv Regev
5. Wolf Reik
6. Alexander Meissner
7. Zachary D. Smith
8. Bing Ren

Citations in the corpus

• Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, background): “In the absence of Stella, TET3 is localized to both paternal and maternal genomes (Nakamura et al., 2012; Wossidlo et al., 2011), and the maternal genome also undergoes 5mC oxidation (Nakamura et al., 2007; Nakamura et al., 2012).”
• Uncovering the role of 5-hydroxymethylcytosine in the epigenome (2011, background): “Expression of Tet3 is by far highest in oocytes and zygotes, where 5hmC levels rise dramatically after fertilization in the male pronucleus”
• Genomic imprinting: the emergence of an epigenetic paradigm (2011, background): “During this time the paternally inherited genome undergoes active DNA demethylation, perhaps through a mechanism involving a hydroxymethylcytosine intermediat”
• A unique regulatory phase of DNA methylation in the early mammalian embryo (2012, background): “Recent evidence implicates a demethylation mechanism that transitions through a hydroxymethylated (hmC) intermediate that is catalyzed by the Tet3 member of the Tet family 8,9 .”
• Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “Role of Tet1 in regulating pluripotency and lineage differentiation of mouse ES cells Concomitant with the rapid reduction of Tet3 expression at the two-cell stage, the expression of Tet1 is rapidly upregulated at later preimplantation stages (Iqbal et al. 2011; Wossidlo et al. 2011).”
• Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome (2012, positive): “The TET proteins, which are responsible for conversion of 5mC to 5hmC, have been shown to function in ESC regulation, myelopoiesis and zygote development (Dawlaty et al., 2011; Gu et al., 2011; Iqbal et al., 2011; Ito et al., 2010; Ko et al., 2010; Koh et al., 2011; Wossidlo et al., 2011).”
• DNA Demethylation Dynamics (2011, methodology): “…modifications of 5hmC coupled with DNA immunoprecipitation and sequencing, chromatographic separation techniques, and improved immunohistochemical visualization using specific antibodies to distinguish 5mC and 5hmC (He et al., 2011; Pastor et al., 2011; Song et al., 2011; Wossidlo et al., 2011).”