Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex.

By J. Radley, H. Sisti, Jiandong Hao, Anne B. Rocher, T. McCall, Patrick R Hof, Bruce S. McEwen, John H. Morrison. Neuroscience, 2004

769 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Endocrine and Autonomic Systems, Social Psychology

View Paper: https://www.semanticscholar.org/paper/4c70f85179b292ebbfc5f70c2b6ca2eac9aee4f9

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Citations in the corpus

Stress- and Allostasis-Induced Brain Plasticity (2011, neutral): “Nevertheless, glucocorticoids do appear to play a role: Three weeks of chronic corticosterone treatment produced retraction of dendrites in medial prefrontal cortex (49), although there were subtle qualitative differences from the effect of chronic restraint stress (50).”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, result): “Chronic restraint stress induces significant regression of the apical dendrites of pyramidal cells in medial prefrontal cortex (mPFC) in rats, an effect similar to that described in area CA3 of the hippocampus (Cook and Wellman, 2004; Radley et al, 2004).”
Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. (2005, background): “Repeated stress causes dendritic shortening in medial prefrontal cortex but produces dendritic growth in neurons in amygdalae [5,9,21,27-30].”
Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. (2008, background): “…shortening in medial prefrontal cortex (Sousa et al., 2000; Wellman, 2001; Vyas et al., 2002; Kreibich and Blendy, 2004; Cook andWellman, 2004; Radley et al., 2004, 2006; Brown et al., 2005) but produces dendritic growth in neurons in amygdala (Vyas et al., 2002), as well as in orbitofrontal…”
The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress (2007, background): “Previously, independent studies (Wellman, 2001; Radley et al., 2004; Brown et al., 2005; Cerqueira et al., 2007) described that chronic stressors or glucocorticoids produce profound rearrangements of the apical dendrites of layer II–III PFC pyramidal neurons, resulting in atrophy of the distal…”
Brain On Stress: Vulnerability and Plasticity of the Prefrontal Cortex Over the Life Course (2013, positive): “As will be discussed in detail in this Review, the homologous mPFC is highly vulnerable to stress (Cook and Wellman, 2004; Holmes and Wellman, 2009; Radley et al., 2004), aging (Bloss et al., 2011), and estrogen depletion (Shansky et al., 2010) in rats.”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “Chronic stress decreases dendritic branching in the hippocampus (McEwen, 2001) and mPFC (Liston et al, 2006; Radley et al, 2004), but increases dendritic branching in the amygdala (Mitra et al, 2005; Vyas et al, 2006).”
Towards a glutamate hypothesis of depression (2011, background): “Quite similar effects of stress have been described in medial prefrontal cortex (Radley et al., 2004).”