The microbiology of butyrate formation in the human colon.

By S. Pryde, S. Duncan, G. Hold, C. Stewart, H. Flint. FEMS Microbiology Letters, 2002

1,300 citations recorded by the source corpus.

Subfields: Food Science, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/4bc8127a776ea19c72d0161c74b463eb864d07de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

1. H. Flint
2. P. Louis
3. S. Duncan
4. K. Scott
5. G. Holtrop
6. W. D. de Vos
7. Pauline Young
8. Jeroen Raes

In Nutrition and Dietetics

1. H. Flint
2. P. Louis
3. S. Duncan
4. K. Scott
5. G. Holtrop
6. Pauline Young
7. G. Lobley
8. A. Belenguer

Citations in the corpus

• Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis (2008, background): “Microbial supply of the short-chain fatty acid butyrate, for example, is thought to contribute to the prevention of colorectal cancer in rats and human”
• Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data (2014, background): “Butyrate-producing bacteria are widespread and can be found in many environments (1) but especially in host-associated sites, including the rumen (2), the mouth (3), and the large intestine (4).”
• Understanding the effects of diet on bacterial metabolism in the large intestine (2007, background): “Butyrate, on the other hand, is the major energy source for the colonocytes, and has been implicated in the prevention of colitis and colorectal cancer (Pryde et al. 2002).”
• The role of pH in determining the species composition of the human colonic microbiota. (2009, neutral): “The balance of bacterial species and their metabolites in the human large intestine is considered to markedly influence the maintenance of gut health (Pryde et al., 2002; Hamer et al., 2008) or progression towards disease (Gill and Rowland, 2002).”
• Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product (2004, background): “It is suggested that this type of cross-feeding might contribute to the reported butyrogenic effect of certain dietary substrates, such as resistant starch in the human colon (13, 33, 40, 50, 56, 58).”
• Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. (2017, background): “Eubacterium rectale is a bacteria known to produce butyrate (an anti-inflammatory compound) that plays key protective roles against inflammation (Pryde et al., 2002).”
• Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes (2011, background): “Butyrate is known as an anti-inflammatory short chain fatty acid that contributes to colon health [31–33].”
• Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: a Cross-Sectional Study (2006, background): “The gut microbiota of vegetarians differs from that of individuals on a Western diet in that the former is dominated by clones belonging to the Clostridium rRNA subcluster XIVa (also called Clostridium coccoides) and the Clostridium rRNA cluster XVIII (also called Clostridium ramosum) (10, 17).”
• pH and Peptide Supply Can Radically Alter Bacterial Populations and Short-Chain Fatty Acid Ratios within Microbial Communities from the Human Colon (2005, background): “Short-chain fatty acids (SCFA) arising from microbial fermentation provide energy sources for the colonic epithelium, and butyrate in particular exerts important effects on cell differentiation and gut health (2, 6, 30, 44, 48, 50).”
• Symbiotic gut microbes modulate human metabolic phenotypes (2008, background): “prausnitzii is the most significant n-butyrateproducing gut bacterium with well known effects on host energy metabolism and mucosal integrity (22).”
• Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. (2013, background): “Early cultural and molecular studies from Flint’s group (37, 38) in Aberdeen, Scotland, indicated that the most numerous butyrateproducing bacteria found in human feces were highly oxygensensitive anaerobes belonging to the Clostridium clusters IV and XIVa.”