Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

By W. R. Wikoff, A. Anfora, Jun Liu, Peter G. Schultz, S. Lesley, E. Peters, Gary Siuzdak. Proceedings of the National Academy of Sciences of the United States of America, 2009

2,528 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4b7366ca3294f6be33ffbe65eb744dfe4874245d

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Citations in the corpus

Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells (2015, background): “Human gut microbial constituents do not appear to make 5-HT, suggesting that alterations in 5-HT signaling in response to bacteria are likely due to changes in host serotonergic expression (11).”
Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases (2016, methodology): “Using LC-MS-based high-resolution metabolomic (HRM) methods, thousands of m/z features (i.e. peaks of MS spectrum) can be consistently detected and quantified from biological samples (Hoffman et al., 2014; Wikoff et al., 2009).”
Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “Circulating levels of many of the amino acids which compete with tryptophan for transport across the BBB such as tyrosine, phenylalanine, isoleucine and valine are also increased in GF animals (Mardinoglu et al., 2015; Wikoff et al., 2009).”
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “Indeed, it has been shown, for example, that in mice almost all blood-derived serotonin is produced by symbiotic bacteria (256).”
Human nutrition, the gut microbiome, and immune system: envisioning the future (2011, background): “The marriage of metagenomics and gnotobiotics We believe that the 'marriage' of two approaches — one involving culture-independent (metagenomic) methods for describing the gut microbiota or microbiome and the other involving gnotobiotics (the rearing of animals under germ-free conditions, with or”
Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis (2016, background): “These animals show increased levels of circulating tryptophan [102] and decreased serotonin [103].”
Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut (2016, background): “Microbial metabolic end-products, which account for one third of the metabolites present in the human blood, play an important role in gut homeostasis and have an impact on host metabolism and health (Wikoff et al., 2009; Hood, 2012; Louis et al., 2014; Sharon et al., 2014; Richards et al., 2016).”
Animals in a bacterial world, a new imperative for the life sciences (2013, background): “, the diversity of molecules carried in its blood – has a microbial origin; thus, the circulatory system extends the chemical impact of the microbiota throughout the human body (79), transporting metabolites that influence the physiology and metabolism of distant organs and, perhaps, other bacterial”
Gut microbiota functions: metabolism of nutrients and other food components (2017, methodology): “The utility of this approach for studying the microbiome has been demonstrated in animal models of altered microbial status, such as germ-free, gnotobiotic, antibiotic-treated animals, and also in human studies [82, 130–132].”
The Human Microbiome: at the interface of health and disease (2012, background): “For example, comparing germ-free and normal mice indicates that microbiota are responsible for most of the metabolites that are detected in plasm”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “Nowhere are the interactions between the microbiota and host more clearly demonstrated than on metabolomic studies on mammalian blood metabolites, Comparison of plasma extracts from germ-free and conventional animals showed that approximately 10 % of all features observed showed significant changes ”
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019, background): “Furthermore, changes in the microbiome often result in altered metabolic proﬁles, impacting the availability and diversity of nutrients and microbial metabolites (Dodd et al., 2017; Melnik et al., 2017; Sharon et al., 2014; Wikoff et al., 2009).”