Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells

By Christopher S. Reigstad, C. Salmonson, John F. Rainey Iii, J. Szurszewski, D. R. Linden, Justin L. Sonnenburg, G. Farrugia, P. Kashyap. The FASEB Journal, 2015

1,156 citations recorded by the source corpus.

Subfields: Gastroenterology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/113d99a18d059c051f5decb598934f7df35725c8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. C. Stanton
6. Ygor P. Silva
7. A. Bernardi
8. R. Frozza

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. P. Kennedy
6. Ygor P. Silva
7. A. Bernardi
8. R. Frozza

In Physiology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton

Citations in the corpus

• SCFA: mechanisms and functional importance in the gut (2020, background): “SCFA also increase serotonin production, and blockade of serotonin receptors decreases butyrate-dependent electrolyte absorption((119,125)).”
• Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “Bacterial metabolites have also been demonstrated to influence Tph1 transcription in a human enterochromaffin cell model (Reigstad et al., 2015).”
• Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “In the intestinal tract, nearly all SCFAs are produced through bacterial fermentation.”
• Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. (2018, neutral): “The mechanisms by which the gut microbiota modulates 5-HT production are not fully understood, but the role of SCFAs in the stimulation of TpH1 expression has been suggested (Reigstad et al., 2015) Moreover some secondary bile acids, such as deoxycholate produced by microbial biotransformation of ch”
• Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations (2018, background): “serotonin) (Chambers et al. 2015; Reigstad et al. 2015), and the induction of vagus nerve signalling (De Vadder et al.”
• Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain. (2019, background): “TPH exists in 2 isoforms: TPH1 is mainly expressed in the ECs and TPH2 is locally expressed in the brain (25).”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “This is consistent with the observation that gastrointestinal serotonin synthesis, which modulates circulating levels, is driven by microbial metabolites such as SCFAs or tryptophan-derived indole metabolites (Reigstad et al., 2015; Yano et al., 2015).”
• The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, background): “In particular, these SCFAs regulate the expression levels of tryptophan 5-hydroxylase 1, the enzyme involved in synthesis of serotonin, and tyrosine hydroxylase, which is involved in a rate-limiting step in the biosynthesis of dopamine, noradrenaline and adrenaline; therefore, producing an effect on”