The Human Microbiome: at the interface of health and disease

By Ilseung Cho, Martin J. Blaser. Nature reviews genetics, 2012

3,155 citations recorded by the source corpus.

Interest in the role of the microbiome in human health has burgeoned over the past decade with the advent of new technologies for interrogating complex microbial communities. The large-scale dynamics of the microbiome can be described by many of the tools and observations used in the study of population ecology. Deciphering the metagenome and its aggregate genetic information can also be used to understand the functional properties of the microbial community. Both the microbiome and metagenome probably have important functions in health and disease; their exploration is a frontier in human genetics.

Subfields: Food Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2a18eef255784593f4bd7aa34d81843efaa6656b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

In Molecular Biology

Citations in the corpus

Induced systemic resistance by beneficial microbes. (2014, background): “However, whereas the human microbiome is limited in its phylogenetic diversity, plants are colonized by extremely diverse communities, especially on their roots (25, 89).”
The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks (2020, background): “Human skin and mucosal surfaces are associated with rich and complex ecosystems (microbiota) composed of bacteria (bacteriobiota), fungi (mycobiota), viruses (virobiota), phages, archaea, protists, and helminths (Cho and Blaser, 2012).”
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019, background): “…yet heritable (Moeller et al., 2018) contributor to behaviors may be the microbiota, a community of microorganisms harbored in our gastrointestinal (GI) tract that impacts development and function of the immune, metabolic, and nervous systems (Cho and Blaser, 2012; San-doval-Motta et al., 2017).”
Defining dysbiosis and its influence on host immunity and disease (2014, background): “Early exposure to these diverse communities of microbes appears to be an additional facet to maintaining a healthy host–microbiota relationship (Cho and Blaser, 2012; Cho et al., 2012).”
MicrobiomeAnalyst 2.0: comprehensive statistical, functional and integrative analysis of microbiome data (2023, neutral): “High-throughput amplicon sequencing has yielded many insights into the de v elopment and progression of human diseases ( 3 ).”
Synchronized cycles of bacterial lysis for in vivo delivery (2016, methodology): “3a-b, Supplementary Videos 4 and 5).”
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences (2013, background): “High-throughput sequencing has facilitated major advances in our understanding of microbial ecology and is now widespread in biotechnological applications from personalized medicine 1 to bioenergy 2 .”
Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries (2014, result): “Such finding corroborates the observation that during the initial stage of gut colonization, microbiota is highly unstable in humans (Palmer et al., 2007; Mariat et al., 2009; Cho and Blaser, 2012) and mice (El Aidy et al., 2012, 2013).”
Colonic bacterial composition in Parkinson's disease (2015, background): “Putative “proinflammatory” and “anti-inflammatory” bacteria taxa were classified based on previous reports (and the references therein).(24-28) Short-chain fatty acids (SCFAs), especially butyrate-producing bacteria at the intestinal level, play a major regulatory role in the intestinal ecosystem to”
Stress Physiology of Lactic Acid Bacteria (2016, background): “Recent metagenomic data support early observations of LAB being a part of the microbiomes of humans and other animals (9, 10).”