The Ki‐67 protein: From the known and the unknown

By T. Scholzen, J. Gerdes. 2000

4,828 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

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Citations in the corpus

Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “Nestin+ proliferating type II INPs also co-labeled with Ki-67, a marker of active cell cycle (Scholzen and Gerdes, 2000), and were found in the SGZ as seen in mice, and in the granule cell layer (GCL) (Figures 1F and 1I–1L), as we have shown in humans (Boldrini et al.”
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. (2011, methodology): “To clarify this question, we analyzed BCR-ABL activity in imatinib-treated quiescent CML cells using Ki-67 negativity as a marker of quiescence (37).”
Bone marrow cells regenerate infarcted myocardium (2001, background): “Ki67 is expressed in cycling cells in G1, S, G2 and early mitosi”
Expression profiling of ependymomas unravels localization and tumor grade‐specific tumorigenesis (2009, background): “In high-grade ependymomas, E2F1 may induce cell proliferation by the activation of genes involved in progression of the cell cycle from G1 phase into S phase.(37) A similar oncogenic stimulation has been described in fibroblast cultures.”
The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. (2002, methodology): “…and Ki-67 as proliferative markers BrdU Ki-67 Selectivity S-phase only (Gratzner, 1982) All phases of cell cycle except G 0 (Endl and Gerdes, 2000; Scholzen and Gerdes, 2000) Delivery and incorporation into tissue Dependent on dose, bioavailability and diffusion barriers (Cameron and McKay, 2001)…”
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. (2002, background): “Furthermore, proliferation, albeit at lowphase of the cell cycle (Scholzen and Gerdes, 2000).”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, positive): “…a single low dose at a low dose-rate, and analyzed proliferation and neurogenesis using endogenous markers for proliferation (Ki67: Kee et al., 2002; Scholzen and Gerdes, 2000) and dividing and differentiating cells of neuronal lineage (doublecortin: Couillard-Despres et al., 2005; and NeuroD: Lee,”
Molecular mechanisms of neurodegeneration in Alzheimer's disease. (2010, background): “identify cells in the progenitor cell (proliferative) phase of neurogenesis [(59,61) Fig.”
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. (2004, background): “Moreover, there was a concomitant elimination of staining for Ki-67, a commonly measured marker of proliferation (83).”