Bone marrow cells regenerate infarcted myocardium
By D. Orlic, J. Kajstura, S. Chimenti, Igor Jakoniuk, S. Anderson, Baosheng Li, J. Pickel, R. McKay, B. Nadal-Ginard, D. Bodine and 2 more. Nature, 2001
5,416 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Genetics, Surgery
View Paper: https://www.semanticscholar.org/paper/22a6e77f414679c22a6225105e7abab7fb6ad8a2
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In Cardiology and Cardiovascular Medicine
In Genetics
- A. Caplan
- P. Robey
- P. Bianco
- A. Wagers
- S. Morrison
- Arturo Alvarez-Buylla
- Kenneth R. Boheler
- A. Wobus
In Surgery
- A. Caplan
- M. Laflamme
- J. Willerson
- Charles E. Murry
- Nikolaos G. Frangogiannis
- TA Wynn
- K. Leong
- B. Chan
Citations in the corpus
- Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts (2004, background): “These results contrast with the work of Orlic et al., who reported extensive cardiac regeneration after direct injection of Lin2 c-kitþ cells into infarcts9.”
- Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium (2004, background): “Consistent with Orlic et al.(7), however, we do find that c-kitþ GFPþ input cells lose expression of the c-kit marker over time.”
- Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. (2005, background): “BM cells appear to have the capacity to repopulate many nonhematopoietic tissues, such as neuroectodermal cells (3, 4), skeletal myoblasts (5), CMCs (6, 7), endothelium (6–8), hepatocytes (9), and lung, gut, and skin epithelia (10).”
- Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes (2003, background): “Several groups have attributed this apparent plasticity to ‘transdifferentiation&rsquo”
- Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts (2003, neutral): “Harvesting BMCs followed by direct injection into ischemic myocardium results in angiogenesis and myogenesi”
- Bone marrow-derived progenitor cells in pulmonary fibrosis. (2004, neutral): “After transplantation of bone marrow (BM) hematopoietic stem cells or nonhematopoietic mesenchymal stem cells, muscle (2), heart (3), liver (4), and lung (5, 6) cells of donor origin have been detected.”