Noggin antagonizes BMP signaling to create a niche for adult neurogenesis.

By Daniel A. Lim, A. D. Tramontin, J. Trevejo, D. G. Herrera, Jose Manuel García-Verdugo, Arturo Alvarez-Buylla. 2000

1,117 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “The BMP action can be antagonized by noggin and neurogenesin-1, which are expressed by SVZ ependymal cells (Lim et al., 2000) and by SGZ astrocytes and granule cells (Ueki et al., 2003) , respectively.”
For the long run: maintaining germinal niches in the adult brain. (2004, background): “The niche for in vivo (Lim et al., 2000). adult neurogenesis may be nothing more than an early Recent work indicates that BMPs act in combination epithelial-like environment, a “pocket” that retains a set with leukemia inhibitory factor (LIF) to sustain self-renewal of developmental signals that…”
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “For example, BMP signaling negatively regulates neurogenesis by promoting SVZNSC astroglial fate commitment and SGZ NSC quiescence (Lim et al., 2000; Mira et al., 2010).”
Erythropoietin Regulates the In Vitro and In Vivo Production of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells (2001, background): “Taken together with recent studies that revealed active ephrin (Conover et al., 2000) and bone morphogenetic protein (Lim et al., 2000) signaling in the adult subventricular zone, our findings further support the role of endogenous local signals, both fixed and diffusible, in regulating adult NSC…”
TGFβ signalling: a complex web in cancer progression (2010, background): “BMP signalling is known to induce the differentiation of embryonic neural progenitor cells into astrocyte”
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. (2010, background): “In the adult brain environment, the contribution of BMP signaling to stem cell regulation remains largely unexplored, although recently it has been suggested that the BMP pathway may have a central role in modulating NSC function (Lim et al., 2000; Coskun et al., 2001; Colak et al., 2008; Bonaguidi ”
Neural induction, the default model and embryonic stem cells (2002, background): “Recent work on adult stem cells indicates that BMP signalling might also act to regulate neurogenesis from these stem cell”
Development of neural stem cell in the adult brain. (2008, background): “On the contrary, bone morphogenic proteins (BMPs) promote glia differentiation of NSCs derived from the adult SVZ [28] and hippocampus in vitro [29].”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “In addition, primary cells from neurogenic areas transplanted into non-neurogenic regions exhibit very limited neurogenesis (reviewed in Herrera et al. 1999; Lim et al. 2000; Temple 2001).”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “The BMP family instructs adult neural stem cells to adopt a glial fate, and, therefore, possibly to adopt the 'default path' as astrocyte”
The glial identity of neural stem cells (2003, background): “Ependymal cells, however, participate in creating a specialized neurogenic niche in the SVZ by producing noggin, an antagonist of bone morphogenetic proteins, which promote astroglial differentiation in this regio”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, background): “, 2000) and its expression in murine SGZ and SVZ was previously reported (Fan et al., 2003; Lim et al., 2000; Tang et al., 2009).”