Uncertainty in the niches that maintain haematopoietic stem cells

By M. Kiel, S. Morrison. Nature reviews. Immunology, 2008

624 citations recorded by the source corpus.

Subfields: Hematology, Hepatology

View Paper: https://www.semanticscholar.org/paper/4a8a11e4d6ae72c618ce5f2596e0723b4206862b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. S. Morrison
2. Lei Ding
3. D. Lyden

In Hepatology

1. S. Morrison

Citations in the corpus

• Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. (2011, background): “At present, the precise cellular composition and location of the HSC niche remains controversial (5, 22).”
• Mechanisms of stem cell self-renewal. (2009, background): “In the mammalian hematopoietic system, some of the key factors required for stem cell maintenance have been identified, but the cells that produce these factors and create the niche remain uncertain (Kiel & Morrison 2008) (Figure 4c).”
• Mesenchymal stem cells in health and disease (2008, background): “The regulation of HSC quiescence, through the maintenance of HSCs in the G0 phase of the cell cycle in the endosteal niche, and the control of HSC proliferation, differentiation and recruitment in the vascular niche can be ascribed to bone-marrow stromal cell”
• The metastatic niche: adapting the foreign soil (2009, background): “The cellular kinetics of bone marrow cells are regulated by a variety of cell types, including osteoblasts,osteoclasts, vascular endothelial and perivascular cell”
• Endothelial and perivascular cells maintain haematopoietic stem cells (2012, background): “In most mammalian tissues, including the haematopoietic system, the identities of the cells that promote stem cell maintenance remain uncertai”
• Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells (2009, neutral): “…with prior reports of a perivascular niche for normal stem cells (Tang et al., 2008; Yoshida et al., 2007) and GSCs (Calabrese et al., 2007) hematopoietic stem cell location in the bone marrow, in which these cells are located around the endosteum and vascular sinusoids (Kiel and Morrison, 2008).”
• The elusive nature and function of mesenchymal stem cells (2011, neutral): “Although the existence of an osteoblastic HSC niche is controversia”