The elusive nature and function of mesenchymal stem cells
By C. Nombela-Arrieta, J. Ritz, L. Silberstein. Nature reviews. Molecular cell biology, 2011
640 citations recorded by the source corpus.
Mesenchymal stem cells (MSCs) are a diverse subset of multipotent precursors present in the stromal fraction of many adult tissues and have drawn intense interest from translational and basic investigators. MSCs have been operationally defined by their ability to differentiate into osteoblasts, adipocytes and chondrocytes after in vitro expansion. Nevertheless, their identity in vivo, heterogeneity, anatomical localization and functional roles in adult tissue homeostasis have remained enigmatic and are only just starting to be uncovered.
Subfields: Genetics, Surgery, Urology
View Paper: https://www.semanticscholar.org/paper/404b6a5a1a2f90c67232f8a9d1acb6ba351fdeae
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Citations in the corpus
- Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “, do they self-renew, and can their progeny differentiate into a functional multiple cell types of a given tissue? The reader is referred to recent excellent reviews that discuss this topic (Garcı́a-Gómez et al., 2010; Nombela-Arrieta et al., 2011).”