Autophagy fights disease through cellular self-digestion

By N. Mizushima, Beth Levine, A. Cuervo, D. Klionsky. Nature, 2008

6,590 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/1065f3592b3b764b5e442e3bcdce07c9bc06e7e5

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Citations in the corpus

An Overview of the Molecular Mechanism of Autophagy (2009, background): “Moreover, autophagy is implicated in a wide range of diseases (Huang and Klionsky 2007; Mizushima et al. 2008; Shintani and Klionsky 2004a), including cancer and neurodegenerative disorders such as Alzheimer', Parkinson' and Huntington' diseases.”
Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, neutral): “Defective autophagy pathway or alterations in autophagy-related genes is shown in various human pathologies including neurodegenerative and lysosomal storage disorders as well as in various cancers (Mizushima et al., 2008; Ravikumar et al., 2010).”
Mitochondrial DNA That Escapes from Autophagy Causes Inflammation and Heart Failure (2012, methodology): “To identify the source of IL-1b and IL-6, we performed in situ hybridization analysis in heart sections.”
LKB1 and AMPK control of mTOR signalling and growth (2009, background): “Autophagy is the process by which cells consume their own proteins and organelles to maintain levels of essential building blocks and promote survival under nutrient-poor conditions (Levine & Kroemer 2008, Mizushima et al. 2008).”
Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Moreover, blocking autophagy has been associated with neurodegenerative diseases such as Parkinson's and Alzheimer's disease (182) (183) (184) .”
A role for ubiquitin in selective autophagy. (2009, background): “…autophagosome, capable of fusion with the lysosome; (2) microautophagy, in which lysosomes invaginate and directly sequester cytosolic components; and (3) chaperone-mediated autophagy (CMA), which involves translocation of unfolded proteins across the lysosomal membrane (Mizushima et al., 2008).”
The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism (2011, neutral): “The most upstream components of the core conserved autophagy pathway include the serine/threonine kinase Atg1 and its associated regulatory subunits Atg13 and Atg17 (ref”
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. (2009, background): “The other major route for the degradation of proteins in eukaryotic cells is through the autophagy–lysosomal system, which includes three main pathways for the delivery of cargo to lysosomes: macroautophagy, microautophagy and chaperone-mediated autophagy (CMA) (21).”
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo (2014, background): “It is possible that these results can be explained by the existence of at least two distinct sources of PtdIns(3)P that are capable of regulating LC3 lipidation.”
Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. (2011, background): “Although starvation-induced autophagy is a bulk protein degradation system that clears long-lived proteins and organelles (Mizushima et al., 2008), there is growing evidence that p62 is an important mediator for targeting Ub proteins to the autophagy system and has a crucial role in the removal of a”
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells (2011, background): “Macroautophagy (hereafter referred to as autophagy) is a cellular degradation system in which cytoplasmic components, including organelles, are sequestered by double membrane structures called autophagosomes and the sequestered materials are degraded by lysosomal hydrolases for supply of amino acids”
Selective autophagy mediated by autophagic adapter proteins (2011, background): “The process is also mobilized in the innate immune response against invading microbes.(1,4,5) Yeast genetics has been vital for the elucidation of the molecular machinery involved in autophagy processes.”