Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

By William E. Dowdle, B. Nyfeler, Jane Nagel, R. Elling, Shanming Liu, E. Triantafellow, Suchithra Menon, Zuncai Wang, Ayako Honda, G. Pardee and 37 more. Nature Cell Biology, 2014

714 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Hematology

View Paper: https://www.semanticscholar.org/paper/f6465938b722d43b5b03abdfd48d6fd6c391906e

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In Cell Biology

1. R. Kang
2. H. J. Zeh
3. Michael Lotze
4. D. Tang

In Epidemiology

1. D. Tang
2. R. Kang
3. H. J. Zeh
4. Michael Lotze
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In Hematology

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Citations in the corpus

• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “Due to these issues, it is of great interest that inhibitors with specificity for the class III PtdIns3Ks, and their consequent effects on autophagy, have been described.(244,1150,1151) A mutant mouse line carrying a floxed allele of Pik3c3 has been created.”
• Mechanisms of Selective Autophagy (2016, neutral): “Under conditions of low intracellular iron, NCOA4 receptors bind specifically to ferritin heavy chains (FTH1) and mediate the delivery of the ferritin complexes into the lysosomal compartment via selective autophagy [19,21,22].”
• Molecular definitions of autophagy and related processes (2017, neutral): “These include (but are likely not limited to): myelinophagy The The EMBO Journal Molecular definitions of autophagy Lorenzo Galluzzi et al (targeting myelin in Schwann cells) (Gomez-Sanchez et al , 2015), zymophagy (targeting zymogen granules in pancreatic acinar cells) (Grasso et al , 2011), granul”
• Autophagy, Metabolism, and Cancer (2015, neutral): “Specific Vps34 inhibitors have been recently developed, and they can suppress the growth and increase the death of cancer cells (3, 71, 72).”
• Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease (2015, background): “NCOA4 was found to interact with the 24-subunit ferritin lattice rather than ferritin monomers in a FTH1-dependent manner [29], but several important aspects of the interaction remain to be characterized, including identification of the NCOA4 and FTH1 interacting domains.”
• Iron metabolism and iron disorders revisited in the hepcidin era (2020, neutral): “Ferritin turnover occurs through “ferritinophagy”, an autophagic process orchestrated by nuclear receptor co-activator (NCOA)4, a cargo molecule that directs ferritin to lysosomal degradation, to recover iron when needed.(25,26) PCBP1 also delivers iron to prolylhydroxylase (PHD2) the enzyme that in”
• Autophagy promotes ferroptosis by degradation of ferritin (2016, background): “Recent studies indicate that increased autophagy can degrade ferritin to increase iron levels resulting in oxidative injury by the Fenton reaction.(11,12) Remarkably, the protein level of FTH1 was significantly increased in ATG5-deficient cells (MEFs and PANC1) with or without erastin treatment (Fig”