Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
By I. Mitroulis, Klara Ruppova, Baomei Wang, Lan-Sun Chen, M. Grzybek, T. Grinenko, A. Eugster, Maria Troullinaki, A. Palladini, I. Kourtzelis and 18 more. Cell, 2018
942 citations recorded by the source corpus.
Summary Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1β and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis. The trained-immunity-related increase in myelopoiesis resulted in a beneficial response to secondary LPS challenge and protection from chemotherapy-induced myelosuppression in mice. Therefore, modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity, which to date, was considered to involve functional changes of mature myeloid cells in the periphery.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/53cb81615eea970f85a48b693045b3e2df29558e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- A. Mantovani
- M. Locati
- G. Curtale
- A. Mildner
- Mihai G. Netea
- L. Joosten
- S. Yona
- F. L. van de Veerdonk
Citations in the corpus
- Developmental and Functional Heterogeneity of Monocytes. (2018, background): “Moreover, histological approaches demonstrated the appearance of macrophages during embryonic development before the establishment of definitive haematopoiesis (Mizoguchi et al., 1992; Naito and Takahashi, 1991; Sorokin and Hoyt, 1992).”
- Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “From an original macrophage-autonomous view, the field moved to involvement of myeloid progenitors and neutrophils (38).”
- Metabolic Induction of Trained Immunity through the Mevalonate Pathway. (2018, positive): “Inhibition of cholesterol synthesis by statins or glycolysis by 2-deoxyglucose (2-DG) blocked the induction of trained immunity by b-glucan in mice (Mitroulis et al., 2018 [this issue ofCell]).”