Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

By Haishan Lin, Ernestine Lee, K. Hestir, Cindy Leo, M. Huang, E. Bosch, R. Halenbeck, Ge Wu, Aileen J. Zhou, Dirk Behrens and 7 more. Science, 2008

786 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/48c799aafe137c0830ca8832412cb9451eaef693

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Citations in the corpus

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Csf-1R is expressed on CDPs, reduced in pre-cDCs, and lost on CD8+ and CD103+ cDCs, but is maintained on a subset of CD11b+ cDCs (Figure 3).”
Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, background): “The two known ligands of Csf-1R, Csf-1/M-CSF (25) and the more recently described IL-34 (26), are both important for the development of this lineage, as M-CSF-deficient mice (op/op and csf1−/−) have a milder phenotype than do Csf-1Rdeficient mice (20).”
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “Experimentally blocking CSF-1R with antibodies leads to a reduction in Ly6C− monocytes (69) and to an associated increase in Ly6C+ monocytes, suggesting the involvement of CSF-1 in the maturation of monocytes from Ly6C+ to Ly6C− (48, 104).”
Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, positive): “Dimerization of the receptor upon binding to CSF-1 or IL-34 leads to a cascade of signaling events which promote proliferation, function, and survival of macrophages [64][65].”
CSF-1 receptor signaling in myeloid cells. (2014, background): “The knownligands for the CSF-1Rare CSF-1 and IL-34 (Lin et al. 2008).”
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages (2012, background): “IL-34 is a recently identified alternative ligand of CSF-1R in mice and humans (Lin et al., 2008; Wei et al., 2010), but its expression has not been characterized in embryonic skin.”
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells (2008, background): “Consistent with this possibility, interleukin-34 (IL-34) has recently been identified as a ligand for M-CSFR in mice and human”
CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain (2014, positive): “Mice lacking either of the two CSF1R ligands, CSF1 (Wegiel et al., 1998) or IL-34 (Wang et al., 2012), also have reduced densities of microglia throughout the CNS.”