Novel Type of Staphylococcal Cassette Chromosome mec Identified in Community-Acquired Methicillin-Resistant Staphylococcus aureus Strains

By X. Ma, Teruyo Ito, C. Tiensasitorn, Mantana Jamklang, P. Chongtrakool, S. Boyle-Vavra, Robert S. Daum, K. Hiramatsu. Antimicrobial Agents and Chemotherapy, 2002

687 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/48c241f42ae9931d3558c2517ec15ebbb084c401

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

In Molecular Biology

In Plant Science

Citations in the corpus

Novel Type V Staphylococcal Cassette Chromosome mec Driven by a Novel Cassette Chromosome Recombinase, ccrC (2004, methodology): “The nucleotide sequences of primers cR1, mA2, mA3, is1, and cLs1 have been described previously (17, 26).”
Pulsed-Field Gel Electrophoresis Typing of Oxacillin-Resistant Staphylococcus aureus Isolates from the United States: Establishing a National Database (2003, background): “SCCmec I and IV carry no other resistance genes (31, 38).”
Antimicrobial resistance: the example of Staphylococcus aureus. (2003, background): “The recent upsurge of community-acquired MRSA infections reported in patients from different countries was associated with the detection of a unique SCCmec, type IV (40).”
Novel Multiplex PCR Assay for Characterization and Concomitant Subtyping of Staphylococcal Cassette Chromosome mec Types I to V in Methicillin-Resistant Staphylococcus aureus (2005, methodology): “The SCCmec typing standard MRSA control strains, including type I (NCTC10442), type II (N315), type III (85/2082), type IVa (CA05), type IVb (8/6-3P), type IVc (MR108), type IVd (JCSC4469), and type V (WIS [WBG8318]-JCSC3624) (Table 1), were obtained from K. Hiramatsu and T. Ito at the Juntendo Univ”
Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. (2008, background): “MRSA produces a penicillin-binding protein with reduced affinity for -lactam antibiotics that is encoded by the mecA gene, which is carried by one of a family of four mobile genetic elements (57, 58).”
Dissemination of New Methicillin-Resistant Staphylococcus aureus Clones in the Community (2002, background): “However, type IV SCCmec is short (21 to 25 kb) compared to the three SCCmecs prevalent in H-MRSA strains (34 to 67 kb) and lacks any antibiotic resistance genes other than mecA (23) (Fig.”
Practice guidelines for the diagnosis and management of skin and soft-tissue infections. (2005, background): “fluoroquinolones, or rifampin; genotypically, they appear not to be related to local hospital strains and to contain type IV SCCmec cassette not typical of hospital isolates [85, 86].”
Genome Sequence of Staphylococcus aureus Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands (2007, background): “The observed gap size is larger in S. aureus N315 than in strain MW2, since SCCmec in strain N315 carries not only -lactam resistance but also determinants for resistance to other antibiotics, whereas MW2 possesses only the -lactam resistance gene mecA ( 23 ).”
Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic (2010, background): “The type IV SCCmec element has been strongly associated with strains causing MRSA infections in patients with no HAMRSA risk factors (212, 565) in the United States and elsewhere.”
Multiplex PCR Strategy for Rapid Identification of Structural Types and Variants of the mec Element in Methicillin-Resistant Staphylococcus aureus (2002, background): “This new mec element has a structure identical to that of mec element I in its mecA complex and in the downstream region but showed variability, from one strain to another, further upstream of the mecA complex (18, 26).”
Staphylococcus epidermidis – the “accidental” pathogen (2009, background): “epidermidis , 10 different SCC mec structures were identified; the short SCC mec type IV elemen”
Classification of Staphylococcal Cassette Chromosome mec (SCCmec): Guidelines for Reporting Novel SCCmec Elements (2009, methodology): “Red arrowheads indicate the ISS of SCC that comprise DR sequences. a ccr genes in the gene complex are indicated in parentheses. b ccrA4B4 genes found in type VIII SCCmec were nearly identical to those in the S. epidermidis SCC-CI element and showed nucleotide identities of 89.6% and 94.5% to those ”