Genome Sequence of Staphylococcus aureus Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands

By T. Baba, T. Bae, O. Schneewind, Fumihiko Takeuchi, K. Hiramatsu. 2007

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Cross‐talk between Staphylococcus aureus leukocidins‐intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome‐dependent manner (2012, background): “Strain Newman was isolated in 1952 from a human infection (Duthie and Lorenz, 1952) and has been used extensively in animal models of staphylococcal disease due to its robust virulence phenotypes (Baba et al., 2008).”
The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus (2014, background): “It can include a number of genes encoding enterotoxins, LukED, a lantibiotic system, and serine proteases, among other uncharacterized factors (112).”
Food Poisoning and Staphylococcus aureus Enterotoxins (2010, background): “aureus, often (but not always) encode virulence determinants, are inserted at specific loci in the chromosome and are associated with either intact or remnant DNA recombinases [107,108].”
Staphylococcus aureus leukocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo (2011, unknown): “S4) (Morinaga et al., 2003; Baba et al., 2008).”
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis (2010, background): “The LukA and LukB polypeptides are encoded by the NWMN_1928 and NWMN_1927genes (Baba et al., 2008), which we have named lukA and lukB respectively.”