Induction and Suppression of RNA Silencing by an Animal Virus

By Hongwei Li, Wanxiang Li, Shou-Wei Ding. Science, 2002

876 citations recorded by the source corpus.

Subfields: Endocrinology, Insect Science, Plant Science

View Paper: https://www.semanticscholar.org/paper/48b40611a9e6e29b0c127e7fc22a0e534d1645f4

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Citations in the corpus

Antiviral immunity directed by small RNAs. (2007, positive): “Drosophila Ago2 was the rst component identied in the antiviral RNA silencing pathway of the animal kingdom (Li et al., 2002).”
The Emerging Field of RNA Nanotechnology (2010, positive): “for guiding the self-assembly of RNA nanoparticles with functionalities such as siRN”
Gene silencing in mammals by small interfering RNAs (2002, background): “It is not clear whether mammalian viruses encode either protein- or RNA-based RNAi inhibitors, but a recent report indicates that a virus shared by insects and plants contains a protein that inhibits RNAi in both plants and Drosophila cell”
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. (2006, background): “Introduction of artificial dsRNA or siRNAs in insects and mammalian cells elicits an effective antiviral response that protects cells against highly lytic viruses (Gitlin et al. 2002; Li et al. 2002; van Rij and Andino 2006).”
Induction and suppression of RNA silencing: insights from viral infections (2005, background): “melanogaster and mosquito cells results in hyper-susceptibility to the Flock House virus (FHV), and the Nodamura and O'nyong-nyong RNA viruses, which coincides with reduced vsRNA accumulatio”
The small RNA profile during Drosophila melanogaster development. (2003, background): “…(FHV) in D. melanogaster S2 cells is associated histone H3 methylation as well as asymmetric DNA methylation (Zilberman et al., 2003) and systemic silenc-with the formation of 21 and 22 nt siRNA (Li et al., 2002), further supporting that RNA viruses can elicit an RNAi ing (Hamilton et al., 2002).”
An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus. (2003, background): “The recent identification of a suppressor of silencing from an insect - infecting virus may indicate that the approach described here could also be developed for overexpression in animals ( Li et al .”
Invertebrate immune systems – not homogeneous, not simple, not well understood (2004, background): “elegans and Drosophila has contributed significantly to unraveling the general properties of RNAi, and an anti-viral context has been shown specifically for Drosophila (100).”