The Emerging Field of RNA Nanotechnology

By Peixuan Guo. Nature Nanotechnology, 2010

705 citations recorded by the source corpus.

RNA can be designed and manipulated just like DNA while having different rules for base-pairing and displaying functions similar to proteins. The large variety of loops and motifs in RNA allow them to fold into numerous complicated structures. This diversity provides a platform for identifying viable building blocks for particle assemblies, substrate binding and manufacture engineering. RNA thermal stability allows production of multivalent nanostructures with defined stoichiometry. Here we review the unique qualities of RNA nanotechnology and their distinct properties inside the body. We describe techniques for constructing RNA nanoparticles from different building blocks and their applications in nanomedicine. Finally, we discuss challenges in predicting and synthesizing RNA and offer some perspectives on the yield and cost of RNA production.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1c1e636d06993a77bf9986b364c08281d0f74d52

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In Molecular Biology

1. Travis A. Meyer
2. P. K. Dutta
3. Yonggang Ke
4. Pengfei Wang
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Citations in the corpus

• The Beauty and Utility of DNA Origami (2017, background): “RNA nanotechnology has grown in parallel along with the development of DNA nanotechnology.(30,31) Nonetheless, the realization of RNA origami had not been reported until 2013, when the Sugiyama(32) and Mao(33,34) groups independently demonstrated the folding of a long single-stranded RNA (ssRNA, !1,”