The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

By Kyeong-Hee Lee, A. Dinner, Chun Tu, G. Campi, S. Raychaudhuri, R. Varma, T. Sims, W. Burack, Hui Wu, Julia Wang and 6 more. Science, 2003

602 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/487d622c5ccd56e1f82daa18d7339350bfb61ae9

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In Immunology

1. Ofer Feinerman
2. G. Altan-Bonnet
3. Michael Loran Dustin
4. Ronald N. Germain
5. J. Orange

Citations in the corpus

• Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses (2005, result): “The macroscopic clustering and spatial reorganization of proteins in the immunological synapse is not required for the early rapid signals we are assessing here [20,47], and hence, the correlation of the formation of this organized multiprotein structure with effective T-cell activation [47] is not ”
• Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76 (2005, background): “Analysis of CD2AP-deficient mice has similarly indicated that T cell activation is induced in the absence of mature immunological synapse”
• Formation and function of the lytic NK-cell immunological synapse (2008, background): “In T cells, this is achieved by TCR internalization through the cSMA”
• A Correction to the Review Titled "Rules for Modeling Signal-Transduction Systems" by W. S. Hlavacek et al. (2006, background): “Chakraborty and co-workers have developed two distinct models of early events in T cell receptor (TCR) signaling that have led to interesting insights and hypotheses about the effects of spatial organization ( 45 ) and cooperative interactions ( 78 ) on signal amplification.”
• Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. (2005, neutral): “However, the precise role of the synapse and its mechanism of formation remain poorly understood (Lee et al., 2002a; Lee et al., 2003).”
• Quantitative challenges in understanding ligand discrimination by αβ T cells (2008, background): “Yet, in their most traightforward incarnations, these models are not compatible ith the S3 characteristics of T cell activation: one can increase pecificity by adding kinetic proofreading steps (there are 20 otential kinetic proofreading steps associated with the 20 tyroine phosphorylations of sites”
• T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. (2006, background): “We conclude that the cSMAC is not involved in sustained Ca signaling, but our observations on microclusters suggest that these structures rapidly acquire the chemical stability of the cSMAC, such that concepts originally applied to interactions in the cSMAC may be useful in understanding kinetics of”