Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.
By A. Douglass, R. Vale. Cell, 2005
787 citations recorded by the source corpus.
Subfields: Immunology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/d54cde14a08741b941c627ae9bfd1149a6eca5f6
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In Immunology
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Lipid rafts: contentious only from simplistic standpoints (2006, background): “A similar conclusion is equally plausible in the case of interactions between activated LCK with the TCR-signalling domain 31 .”
- T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. (2006, background): “This submicron exclusion zone may allow increased phosphorylation by tyrosine kinases in the cluster, including CD45-primed Lck that diffuses into the clusters from surrounding CD45-rich domains as recently demonstrated by single molecule imaging (Douglass and Vale, 2005).”
- TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation (2009, methodology): “Long-range diffusion, as measured by dcFCCS, and as seen by single-molecule tracking of CD2, Lat and the kinase Lc”
- Advances in Planar Lipid Bilayers and Liposomes (2011, background): “Cell electroporation is a popular technology and biomedical applications of in vivo cell electropermeabilization [4] are gaining momentum for drug and nucleic acids electrotransfer and for the destruction of tumor cells for cancer treatment [5].”
- Inaugural Article: Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function (2010, neutral): “The shape of the MSD curve can yield insight into the nature of the transport (13, 14).”
- Nonequilibrium physics in biology (2019, background): “…coats during early phases of endocytosis (Faini et al., 2013), receptors (Maddock and Shapiro, 1993; Uhles et al., 2003), SNARE proteins (Low et al., 2006), and proteins involved in signaling (Bonny et al., 2016; Douglass and Vale, 2005; Fairn et al., 2011; Goswami et al., 2008; Tian et al., 2007).”
- Revitalizing membrane rafts: new tools and insights (2010, background): “A non-raft mutant of LAT lacking palmitoylation sites was also trapped by the microclusters, whereas a raft-associated construct, the lipid-modified amino terminus of LCK, was not concentrated in the microcluster”