Formation and function of the lytic NK-cell immunological synapse

By J. Orange. Nature reviews. Immunology, 2008

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Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “Each of the two processes, granule polarization and degranulation, involves multiple intermediate steps (10), such as dynein-dependent transport of granules to the MTOC, docking of the MTOC at the plasma membrane, docking and priming of granules at the plasma membrane, and fusion of granules with th”
Pre-activation with IL-12, IL-15, and IL-18 induces CD25 and a functional high affinity IL-2 receptor on human cytokine-induced memory-like NK cells (2014, background): “Picomolar Concentrations of IL-2 Act via IL-2Rabg to Augment Cytotoxicity by Cytokine-Preactivated NK Cells Resting CD56dim NK cells mediate cytotoxicity when triggered by the appropriate target cell [1,32].”
Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors (2020, background): “As such, perforin and other lytic effector molecules would be secreted/concentrated within a stable immune synapse for efficient killing.(41,42) With reporter cell assays, we show that targeting a membraneproximal epitope resulted in preferential activation of the FcγR-IIIA, but not FcγR-I or -IIA, ”