The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

By P. Wei, Jun Zhang, Margarete Egan-Hafley, Shuguang Liang, D. Moore. Nature, 2000

672 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/097250f077d70f04e67b9a4b99b177b204b1fcc2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. J. Y. Chiang

In Pharmacology

1. B. Goodwin
2. S. Kliewer
3. T. Willson

Citations in the corpus

• Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. (2002, background): “Mice lacking either of these receptors are hypersensitive to treatment with various xenobiotics, including the anesthetic tribromoethanol and the muscle relaxant zoxazolamine (Wei et al., 2000; Xie et al., 2000a).”
• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. (2002, background): “rupted by homologous recombination (145).”