Regulation of circRNA biogenesis
By Ling-Ling Chen, Li Yang. RNA Biology, 2015
1,761 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/77b88c9799029345d522c8eb9213d5a512ed3ea7
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In Cancer Research
In Molecular Biology
Citations in the corpus
- Diverse alternative back-splicing and alternative splicing landscape of circular RNAs (2016, neutral): “As it has been suggested that back-splicing is unfavorably processed by the spliceosome (Jeck and Sharpless 2014; Chen and Yang 2015; Starke et al. 2015; Zhang et al. 2016), it is unclear how the spliceosome could specifically recognize these exons during back-splicing but not during canonical…”
- Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. (2017, background): “It is becoming increasingly evident that circRNAs are not simply by-products of mis-spliced RNAs or splicing errors, but rather, they are the products of regulated backspliced RNAs with distinct sets of cis-elements and/or transfactors [14].”
- Circular RNA: A new star of noncoding RNAs. (2015, background): “This model suggests that the mechanism of alternative circularization is very complicated and is also possibly regulated by other factors, such as RBPs [1].”
- CircRNA: a novel type of biomarker for cancer (2017, background): “CircRNAs shape a covalently closed continuous loop which own relatively jarless framework in the eukaryotic transcriptome [6, 10].”
- mRNA-based therapeutics: powerful and versatile tools to combat diseases (2022, background): “CircRNA is generated by back-splicing, in which the 3′-end of an exon ligates to the 5′-end of its own or an upstream exon through a 3′,5′phosphodiester bond, forming a closed structure.(100) The unique structure of circRNAs gives them greater stability, longer half-life, and greater RNase R resista”
- Circbank: a comprehensive database for circRNA with standard nomenclature (2019, background): “Circular RNAs (circRNAs) constitute a class of RNAs that is characterized by a covalently closed cyclic structure lacking poly-adenylated tails [1,2]. circRNAs are generally expressed at low levels and often exhibit cell type-specific and tissue-specific patterns [3 – 5].”
- Circular RNA: metabolism, functions and interactions with proteins (2020, methodology): “CircRNA is generated by a special alternative splicing manner termed backsplicing, in which the 3′-end of an exon ligates to the 5′-end of its own or an upstream exon through a 3′,5′phosphodiester bond, forming a closed structure with a back-splicing junction site [7, 8, 26].”
- Circular RNA circMTO1 acts as the sponge of microRNA‐9 to suppress hepatocellular carcinoma progression (2017, background): “Unlike linear RNAs terminated with 50caps and 30tails, circRNAs are characterized by covalently closed loop structures with neither 50 to 30 polarity nor polyadenylated tail.((1,2)) circRNAs are conserved and stable, and numerous circRNAs seem to be specifically expressed in a given cell type or”