Circular RNA Expression: Its Potential Regulation and Function
By Julia Salzman. Trends in Genetics, 2016
749 citations recorded by the source corpus.
In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. This feature of gene expression was first recognized in humans and mouse, but it quickly emerged that it was common across essentially all eukaryotes studied by molecular biologists. CircRNA abundance, and even which alternatively spliced circRNA isoforms are expressed, varies by cell type and can exceed the abundance of the traditional linear mRNA or ncRNA transcript. CircRNAs are enriched in the brain and increase in abundance during fetal development. Together, these features raise fundamental questions regarding the regulation of circRNA in cis and in trans, and its function.
Subfields: Cancer Research, Mechanics of Materials, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3e1630cd6716c36f3529d836ad3e134e95cbbef6
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Citations in the corpus
- Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “We now know that transcripts do not have to be linear, with the discovery that circular RNA (circRNA) is a common form of transcribed RNA [17,18].”