Circular RNAs are abundant, conserved, and associated with ALU repeats.

By William R. Jeck, J. Sorrentino, Kai Wang, Michael K. Slevin, C. Burd, Jinze Liu, W. Marzluff, N. Sharpless. RNA: A publication of the RNA Society, 2013

4,015 citations recorded by the source corpus.

Subfields: Mechanics of Materials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/61d3ee2ffb35b66d7a0f3f3bce2439074c1751ce

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In Mechanics of Materials

In Molecular Biology

Citations in the corpus

Regulation of circRNA biogenesis (2015, methodology): “Two models have been proposed to explain the underlying mechanism of back-spliced circularization.(11,16,18,20,28) Broadly speaking, the notable difference between these 2 models is which step, canonical splicing or back-splicing, happens first (Fig.”
Circular RNA Expression: Its Potential Regulation and Function (2016, background): “While circRNAs were first discovered to be ubiquitous in the transcriptomes of humans and mice, they were subsequently found to be abundant in an array of other metazoans, including flies and worms [4,5].”
Using circular RNA as a novel type of biomarker in the screening of gastric cancer. (2015, background): “CircRNAs are widely expressed in human cells, and their expression levels can be 10-fold or higher compared to their linear isomers [10, 21].”
Short intronic repeat sequences facilitate circular RNA production (2014, background): “These highly stable transcripts contain almost exclusively exonic sequences, localize to the cytoplasm, and, at least in two cases, function as efficient modulators of microRNA activity (Hansen et al. 2013; Memczak et al. 2013).”
A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis (2018, background): “found that circRNAs comprise more than 14% of all transcribed genes in fibroblasts; both studies suggest the abundance of circRNAs in the transcriptome [10, 20].”
Circular RNAs: analysis, expression and potential functions (2016, background): “, 2013); natural circRNAs do not appear to be translated (Guo et al., 2014; Jeck et al., 2013), although research has established that manufactured circRNAs designed with an internal ribosome entry site (IRES) can be translated in vitro and in vivo (Chen and Sarnow, 1995; Perriman and Ares, 1998); c”
Genomewide analysis of Drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation (2014, positive): “Human circular RNAs are enriched for flanking Alu repeat elements , especially in complementary orientation (Jeck et al., 2013).”