Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

By J. Nabhan, Ruoxi Hu, R. Oh, Stanley N Cohen, Q. Lu. Proceedings of the National Academy of Sciences of the United States of America, 2012

632 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/461b377751cd289aee6585380595cda9cb48ef68

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Citations in the corpus

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. (2012, background): “However, increasing evidence now indicates Exosome Homogenous population with a size of 40–100 nm in diameter End of endocytic pathway, released from cells when multivesicular bodies fuse with the plasma membrane (16,103,117) Exosomal markers include CD9, CD63, Alix, flotillin-1 and Tsg101 ESCRT is ”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “…recruitment of the ESCRT-I subunit TSG101 to the plasma membrane through its binding to a tetrapeptide protein within the Arrestin 1 domain–containing protein 1 (ARRDC1), resulting in the release of MVs containing TSG101, ARRDC1, and other cellular proteins (Nabhan et al. 2012; Tauro et al. 2012).”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “Some vesicles that have a diameter of >150 nm can be generated by an endosomal pathway [29], and other vesicles of <150 nm in diameter can bleb directly from the plasma membrane [30, 31].”
Biomolecular Fluorescence Complementation Profiling and Artificial Intelligence Structure Prediction of the Kaposi’s Sarcoma-Associated Herpesvirus ORF18 and ORF30 Interaction (2022, neutral): “mCherry-TSG101 [27] (Addgene plasmid # 38318; gifted from Dr.”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “Nabhan and co-workers showed that budding at the PM is driven by the interaction of the TSG101 subunit of ESCRT-I with the tetrapeptide PSAP motif of arrestin domain-containing protein 1 (ARRDC1); the N-terminal arrestin domain of ARRDC1 directs PM targeting [55].”
SORTING IT OUT: REGULATION OF EXOSOME LOADING (2014, background): “These vesicles are CD63-negative and their secretion seems to be driven by interaction of the PSAP motif of ARRDC with the UEV motif of tsg101.”
Advances in therapeutic applications of extracellular vesicles (2019, background): “Using chimeric proteins consisting of a protein of interest fused to ARRDC1, which drives the budding of ARMMs from the plasma membrane (144), the authors demonstrated functional delivery of the tumor suppressor p53 protein (ARRDC1-p53) in vivo.”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “Localization of gag or ARRDC1 at the PM directs EV outward budding there, instead of into MVBs.”
Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “Interestingly, a recent study provided evidence for the recruitment of the ESCRT-I subunit Tsg101 to the plasma membrane by means of a tetrapeptide PSAP motif that drives the ARRDC1 (Arrestin 1 domain–containing protein 1) into MVs (Nabhan et al., 2012).”
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes (2012, background): “Note that truncated forms of Alix containing the V domain interact with the two parts of the N-Ter domain of syntenin that contain LYPXL motifs, (1-30) and (31-60), and that mutation of the three LYPXL motifs (YP to AA) abolishes the interaction.”