The interface between innate and adaptive immunity

By K. Hoebe, E. Janssen, B. Beutler. Nature Immunology, 2004

958 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/45e1fb06c9b0b41d051bd672699ef380d060e085

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. Himanshu Kumar
4. Mihai G. Netea
5. N. Gow
6. Gordon D. Brown
7. J. Mege
8. B. Lee

Citations in the corpus

• Pathogen Recognition by the Innate Immune System (2011, background): “Adaptive immunity is mediated via the generation of pathogen (antigen)-specific B and T lymphocytes through a process of gene rearrangement [7, 8].”
• Exosomes and their roles in immune regulation and cancer. (2015, background): “[53] Hoebe K, Janssen E, Beutler B.”
• An integrated model of the recognition of Candida albicans by the innate immune system (2008, background): “Only in the past decade has it become clear that the innate immune system not only specifically recognizes various classes of microorganisms, it also initiates and modulates the subsequent adaptive responses that are delivered by T-cells and B cells through their interactions with antigen-presenting”
• Recent advances in the innate immunity of invertebrate animals. (2005, background): “The innate immune system is the first line of inducible host defense against bacterial, fungal, and viral pathogens (Hoebe et al., 2004).”
• Paradoxical roles of the immune system during cancer development (2006, background): “Adaptive immunity, inflammation and cancer Recent advances in understanding underlying mechanisms of chronic autoimmune diseases have revealed that adaptive immunity has a crucial role in regulating and activating innate immune cells in affected tissue”
• Macrophage Polarization in Bacterial Infections (2008, background): “A ntigen-presenting cells such as monocytes/macrophages play major roles as sentinels for first line alerts or as mediators that shape the adaptive immune response (1).”
• Mechanisms of Action of Adjuvants (2013, background): “Available evidence suggests that adjuvants employ one or more of the following mechanisms to elicit immune responses: (1) sustained release of antigen at the site of injection (depot effect), (2) up-regulation of cytokines and chemokines, (3) cellular recruitment at the site of injection, (4) increa”