Monocyte and macrophage heterogeneity

By S. Gordon, P. Taylor. Nature reviews. Immunology, 2005

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View Paper: https://www.semanticscholar.org/paper/45bf432df528b35711393c10dfe73b36edbe2f28

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Citations in the corpus

Gender bias in autoimmunity is influenced by microbiota (2013, background): “Additionally, an upregulation of Chitinase-3-like protease 1 gene (Chi3l-1) suggested a more abundant presence of the tolerogenic ‘‘alternatively activated’’ or M2 macrophages (Gordon and Taylor, 2005; Loke et al., 2002; Raes et al., 2002) in SPF males.”
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility (2010, background): “Inspection of the genes listed in Table 6 shows that several of them, including CX3CR1, CD209, CLEC10A, FCER1A, FCGBP, C1RL, C1QB, CD36, ADM and VSIG4, encode proteins involved in the differentiation or maturation of immunity-related cells and in host defence [32–38].”
Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component. (2009, background): “M2 activated macrophages express IL-12, IL-23, and IL-10high; have high levels of scavenger, mannose, and galactose receptors; produce arginase in the place of arginine, subsequently producing ornithine and polyamines; are involved in polarized Th2 reactions; and possess the ability to facilitate ti”
The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “Erythrocytes and platelets are non-phagocytic, and most circulating WBC must be activated at the site of injury to exert their defence functions [26,27].”
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. (2014, background): “Macrophages are heterogeneous, and based on patterns of gene expression and function, they have been classified as classically (M1) or alternatively (M2) activated (Gordon and Taylor, 2005).”
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. (2007, background): “Thus monocyte recruitment into lesions may require CCR2 expression, a feature of the Ly-6Chi subtype (19).”
Exploring the full spectrum of macrophage activation (2008, background): “They differentiate from circulating peripheral-blood mononuclear cells (PBMCs), which migrate into tissue in the steady state or in response to inflammatio”
Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment (2016, background): “Analogously to the T helper (Th1) and Th2 dichotomy, macrophages have been classified into specific M1-like (activated) or M2-like (alternatively activated) functional status based on functional polarization by the microenvironment [13, 14].”
Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. (2012, background): “Macrophage phenotype has been broadly characterized as M1, or “classically” activated, and M2, or “alternatively” activated, mimicking the Th1/Th2 nomenclature [15]; however, it is well recognized that macrophages are a heterogeneous cell population and that M1 and M2 represent extremes on a spectru”
Protective and pathogenic functions of macrophage subsets (2011, background): “Tissue distribution of macrophages Macrophages are divided into subpopulations based on their anatomical location and functional phenotyp”