Gender bias in autoimmunity is influenced by microbiota
By Leonid A. Yurkovetskiy, Michael P. Burrows, Aly A. Khan, Laura Graham, Pavel Volchkov, L. Becker, Dionysios A. Antonopoulos, Y. Umesaki, A. Chervonsky. Immunity, 2013
842 citations recorded by the source corpus.
Summary Gender bias and the role of sex hormones in autoimmune diseases are well established. In specific pathogen-free (SPF) non-obese diabetic (NOD) mice, females have 1.3–4.4 times higher incidence of Type 1 diabetes (T1D). Germ-free (GF) mice lost the gender bias (female/male ratio 1.1–1.2). Gut microbiota differed in males and females, a trend reversed by male castration confirming that androgens influence gut microbiota. Colonization of GF NOD mice with defined microbiota revealed that some, but not all, lineages overrepresented in male mice supported a gender bias in T1D. Although, protection of males did not correlate with blood androgen concentration, hormone-supported expansion of selected microbial lineages may work as a positive feedback mechanism contributing to the sexual dimorphism of autoimmune diseases. Gene expression analysis suggested pathways involved in protection of males from T1D by microbiota. Our results favor a two-signal model of gender bias, in which hormones and microbes together trigger protective pathways.
Subfields: Dermatology, Molecular Biology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/54b15c6cd34680a257017964ddd03fb5d80dd036
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Citations in the corpus
- Role of the Microbiota in Immunity and inflammation (2014, background): “…this sexual dimorphism is also dependent upon the microbiota, as it is not seen in germ-free mice, and the transfer of a male microbiota to females equalizes the incidence of the disease as a result of changes in the expression of sex hormones (Markle et al., 2013; Yurkovetskiy et al., 2013).”
- Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases (2019, background): “(547) Intestinal dysbiosis, circulating gut-derived lipopolysaccharides, and weakening of the intestinal mucosal barrier have already been described in patients with AIH(548,549); and changes in the intestinal microbiome have been associated with female bias in autoimmune disease.(550-552) Future in”
- Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences (2014, background): “As in other animal models of disease, we found variability in the timing and extent of phenotype emergence with notable gender differences (Markle et al., 2013; Pettersson et al., 2012; Yurkovetskiy et al., 2013).”
- Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria (2017, background): “The onset and incidence of autoimmune diabetes is affected by sex hormones (40, 41).”
- Sex differences and hormonal effects on gut microbiota composition in mice (2016, background): “Recent studies with pathogen-free nonobese diabetic (NOD) mice have shown a causal relationship between sex hormones, gut microbiota, and control of autoimmunity.(17,18) Both studies demonstrated that colonization of germ free NOD mice with defined microbiota lead to changes in hormone levels and th”