Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
By Yukio Horikawa, N. Oda, Nancy J. Cox, Xiangquan Li, M. Orho-Melander, M. Hara, Y. Hinokio, T. Lindner, H. Mashima, P. Schwarz and 16 more. Nature Genetics, 2000
1,471 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4545d66a1b1d0010f3e4bafd20920e41b2faa556
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In Cell Biology
In Molecular Biology
- J. K. Pritchard
- Philippe Froguel
- Toshimasa Yamauchi
- Nancy J. Cox
- M. White
- Takashi Kadowaki
- Anthony J. Cesare
- Kenneth S. Kendler
Citations in the corpus
- Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. (2002, background): “…SNPs in the calpain-10 gene that are associated with type 2 diabetes is still unclear, despite extensive efforts directed toward both SNP detection and genotyping in multiple, large samples (Altshuler et al. 2000a; Horikawa et al. 2000; Weiss and Terwilliger 2000; Cox 2001; Evans et al. 2001).”
- Linkage disequilibrium in humans: models and data. (2001, background): “LD plays a fundamental role in gene mapping, both as a tool for fine mapping of complex disease genes (e.g., see Horikawa et al. 2000) and in proposed genomewide association studies (Risch and Merikangas 1996).”
- Neuregulin 1 and susceptibility to schizophrenia. (2002, background): “Alternatively, the functional variant may include more than one polymorphic site, and a haplotype may be necessary to account for the susceptibility, as has been suggested for other complex diseases (Drysdale et al. 2000; Horikawa et al. 2000).”
- IRS proteins and the common path to diabetes. (2002, background): “Consequently, linkage analysis with well defined populations has made slow progress, although a possible role for the serine protease CAPN10 was recently revealed ( 43 , 78).”
- Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. (2002, background): “It is noteworthy that intronic SNPs in CAPN10 (16) or COL1A1 (17) affect the expression levels of these genes.”
- New IBD genetics: common pathways with other diseases (2011, background): “HNF4A and CAPN10 are noteworthy as they are the MODY1 (maturityonset diabetes of the young) and NIDDM1 genes respectively.(134) 135 Both HNF4A and CAPN10 are specifically ulcerative colitis genes,(40) 115 the latter arising from a paediatric gene-discovery cohort.”