Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

By K. Hara, P. Boutin, Y. Mori, K. Tobe, C. Dina, K. Yasuda, Toshimasa Yamauchi, S. Otabe, T. Okada, K. Eto and 14 more. Diabetes, 2002

737 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/1c236e219c4e944e6778aed5d4441336c818add1

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In Endocrine and Autonomic Systems

In Epidemiology

In Physiology

Citations in the corpus

Obesity and the role of adipose tissue in inflammation and metabolism. (2006, background): “In addition, several polymorphisms of the adiponectin gene (APM1, mapped to chromosome 3q27) have been identified that are associated with reduced plasma adiponectin concentration (11–13) and that increase the risk of type 2 diabetes, insulin resistance, or the metabolic syndrome (11, 12, 14).”
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, neutral): “located, and a quantitative-trait locus strongly linked to the MS in individuals of European and Asian descent have previously been identified (129, 256, 664).”
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 (2002, background): “SNPs in the gene encoding adiponectin, accompany hypoadiponectinemia, and are linked to insulin resistanc”
Adipose Tissue (2006, positive): “Genetic evidence has highlighted the region around 3q27 encoding the adiponectin locus as a susceptibility region for syndrome X, and many studies have associated mutations and polymorphisms in the gene encoding adiponectin with an increased prevalence of diabetes (22,23).”
Adiponectin: more than just another fat cell hormone? (2003, background): “(64) found that genetic variations resulting in reduced serum adiponectin levels are associated with increased risk for type 2 diabetes in the Japanese population.”
The role of the novel adipocyte-derived hormone adiponectin in human disease. (2003, background): “Evidence of an association between type 2 diabetes and single nucleotide polymorphisms at positions 45 and 276 ( 48 , 49), and in the proximal promoter and exon 3 (50) of the adiponectin gene has been reported.”
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis Through Adipose Tissue Crosstalk (2016, background): “…findings are robustly supported by human studies demonstrating that, independent of total body fat mass, adipose tissue dysfunction, inflammation, and an imbalance of circulating adipokines are associated with insulin resistance in obese individuals (Hardy et al., 2011; Klöting et al., 2010).”
Adiponectin and adiponectin receptors. (2005, background): “In addition to the relatively common SNPs, eight mutations in the human adiponectin gene have been reported (69, 74, 75), some of which were significantly related to diabetes and hypoadiponectinemia (23, 75).”