Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.

By R. Straub, Yuxin Jiang, C. Maclean, Yunlong Ma, B. Webb, M. Myakishev, C. Harris-Kerr, B. Wormley, H. Sadek, B. Kadambi and 6 more. American Journal of Human Genetics, 2002

846 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ad555fa3f344825168e7b32a50f4c5de58347f96

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Citations in the corpus

Interneuron dysfunction in psychiatric disorders (2012, neutral): “66 ), another important schizophrenia susceptibility gen”
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects (2016, neutral): “…glutamatergic ionotropic receptors and protein complexes such as the ARC complex and DGC. Modest CNV evidence implicating Dystrophin (DMD) and its binding partners is intriguing given that the involvement of certain components of the DGC have been postulated 29 , 30 and disputed 31 previously.”
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. (2004, background): “Additional synaptic proteins such as neuregulin1 (NRG1), dysbindin and regulator of G-protein signaling 4 (RGS4) have been implicated as susceptibility genes for schizophrenia [3,14, 15 ] and preliminary evidence suggests that each of these proteins is abnormally expressed in schizophrenic prefronta”
The genetics of schizophrenia and bipolar disorder: dissecting psychosis (2005, background): “Evidence implicating dystrobrevin binding protein 1 ( DTNBP1 ), also known as dysbindin , in schizophrenia was first reported by Straub et al , 21 who undertook association mapping across the linkage region on chromosome 6p22.”
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. (2003, methodology): “Straub et al. (2002b) typed three different interdigitated 30-cM marker maps (with follow-up of positive scores) in each of three pedigree subsets , which were treated here as three independent scans; the Finnish group separately analyzed families from the general Finnish population and from a…”
The future of association studies: gene-based analysis and replication. (2004, background): “Following an initial study by Straub et al. (2002) that demonstrated an association with schizophrenia and dysbindin, located at 6p22.”
Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. (2003, neutral): “For double-proband pairs, the equation is as follows: ( 5 ) ( 2� )/2�”