New IBD genetics: common pathways with other diseases

By C. Lees, J. Barrett, M. Parkes, J. Satsangi. Gut, 2011

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The gut microbiota and inflammatory bowel disease (2014, positive): “The physiological functions of these genes are categorized into several groups relating to (1) acquired immunity ( IL23R , IL12B , JAK2 , STAT3 ), (2) bacterial recognition and processing ( NOD2/CARD15 ), (3) autophagy ( ATG16L , IRGM , ATG5 ), and (4) mucosal barrier ( ECM1 , CDH1 , LAMB1 ) [37].”
Genetic determinants of the gut microbiome in UK Twins (2016, positive): “Within a SNP set associated with IBD (Jostins et al., 2012), we detected a suggestive association (permutation P-value = 0.056) driven by the genus SMB53 and variants in the gene GNA12, involved in barrier defense and associated with ulcerative colitis (Lees et al., 2011).”
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data (2013, background): “…aneurysms 3 ; variants in the human leukocyte antigen (HLA) region and IL23R , which were associated initially with inflammatory bowel disease 4 and subsequently with a variety of other autoimmune diseases 5,6 ; and PTPN22 R602W, which was associated initially with lower risk of Crohn’s…”