Neuregulin 1 and susceptibility to schizophrenia.

By Hreinn Stefansson, E. Sigurdsson, V. Steinthorsdottir, S. Bjornsdottir, T. Sigmundsson, Shyamali Ghosh, J. Brynjólfsson, Steinunn Gunnarsdottir, Ó. Ívarsson, T. T. Chou and 28 more. American Journal of Human Genetics, 2002

1,691 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d0dc965e085d7fd4a486a77eeb2d0dfd3e74000b

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Citations in the corpus

Neuregulins: functions, forms, and signaling strategies. (2003, background): “Consistent with the idea that impairment of NRG1 signaling contributes to the pathology of schizophrenia, mice heterozygous for two different mutations in the NRG1 gene or a null mutation of the ErbB4 gene display hyperactivity in behavioral tests similar to hyperactivity observed in mice treated wi”
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia (2008, background): “Nrg1 +/− mice show a decrease in the number of functional NMDA receptors in their forebrai”
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. (2004, background): “For example, NRG1 regulates the expression of glutamate receptor subunits and activates ErbB4 receptors, which are colocalized with NMDA receptors and regulate aspects of NMDA signaling [ 14 ].”
The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. (2006, background): “The potential of linkage mapping for gene identification in complex diseases was highlighted in studies of type 2 diabetes, Crohn’s disease, and schizophrenia (Stefansson et al., 2002).”
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders (2007, neutral): “Consistent with this, activation of neuregulin 1, a growth factor genetically linked to schizophrenia in human”
The genetics of schizophrenia and bipolar disorder: dissecting psychosis (2005, background): “43 Only the two deCODE studies 32 33 and our own UK study have implicated the specific Icelandic haplotype, perhaps reflecting differences in the LD structure across NRG1 in European and Asian samples.”
The epidermal growth factor receptor family: Biology driving targeted therapeutics (2008, background): “Similarly, neuregulin-1-ErbB4 signaling has also been implicated in the pathogenesis of schizophrenia based on association between neuregulin-1 polymorphisms and the disease in some populations [143-145].”
Signals of recent positive selection in a worldwide sample of human populations. (2009, methodology): “We implemented a database of our results based on the generic genome browser (Stein et al. 2002), available at http://hgdp.uchicago.edu.”
Animal models of schizophrenia (2011, background): “They also show subtle impairments in PPI of acoustic startle (Stefansson et al., 2002; O’Tuathaigh et al., 2007; van den Buuse et al., 2009).”
The origin and specification of cortical interneurons (2006, neutral): “Several mouse models have been generated in which the abnormal development or function of interneurons is thought to produce behavioural abnormalities similar to those seen in humans with schizophreni”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, positive): “Both AKT1 and its upstream activator NRG1 have been identified as susceptibility genes for schizophrenia (Emamian et al., 2004; Mei and Xiong, 2008; Stefansson et al., 2002; Tosato et al., 2005).”