IRS proteins and the common path to diabetes.

By M. White. American Journal of Physiology. Endocrinology and Metabolism, 2002

968 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/5c214e2b2953d3bb3368f81b4a091175e164347f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. M. Wymann
2. R. Schneiter
3. Jianping Ye
4. M. Quon
5. K. Koh
6. M. Montagnani
7. H. Ruan
8. H. Lodish

In Molecular Biology

1. M. Wymann
2. Jianping Ye
3. R. Schneiter
4. H. Ruan
5. H. Lodish
6. G. Hotamışlıgil

In Surgery

1. M. Wymann
2. Jianping Ye
3. M. Quon
4. K. Koh
5. M. Montagnani
6. R. Schneiter
7. H. Ruan
8. H. Lodish

Citations in the corpus

• Inflammation and metabolic disorders (2006, background): “Inflammatory signalling and insulin action How do inflammatory signals disrupt insulin action and mediate insulin resistance in obesity? The insulin signalling pathway is not presented here in detail because of space limitations, and readers are referred to excellent recent review”
• The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins (2004, background): “The signal transduction mechanisms operating downstream of insulin receptor ligation have highlighted the importance both of the receptor tyrosine kinase substrates (insulin receptor substrates, IRS-1 and IRS-2) and the lipid kinase phosphoinositide 3-OH kinase (PI3K; Saltiel, 2001; Saltiel and Kahn”
• Cardiovascular actions of insulin. (2007, background): “The insulin receptor (IR), a ligand-activated tyrosine kinase, phosphorylates intracellular substrates including IR substrate (IRS) family members and Shc that serve as docking proteins for downstream signaling molecules (10).”
• Lipid signalling in disease (2008, background): “Among other substrates, insulin stimulates tyrosine phosphorylation of insulin receptor substrate (IRS”
• Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. (2003, background): “Insulin signal transduction and its pertinence to systemic insulin sensitivity has been the topic of a number of recent reviews [13,14,21–25].”
• Mechanisms of insulin resistance in obesity (2013, background): “The first is inhibition of IRS-1 (insulin receptor substrate 1) and insulin receptor in the insulin signaling pathway [19,20].”
• Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways (2008, positive): “In addition, miR-145 has been shown to translationally inhibit insulin receptor substrate 1 and IRS-1 in turn has been linked to variousforms of insulin resistance [58,60,70,71].”